Bryson E C, Levin L, Banchs F, Abbott P V, Trope M
Department of Endodontics, School of Dentistry, UNC at Chapel Hill, Chapel Hill, NC 27955, USA; Oral Health Centre of WA and School of Dentistry, The University of Western Australia, Perth, Australia.
Dent Traumatol. 2002 Dec;18(6):316-21. doi: 10.1034/j.1600-9657.2002.00142.x.
Ledermix Paste is a paste containing triamcinolone and demeclocycline with demonstrated anti-inflammatory activity that may slow down resorptive processes after severe traumatic injuries to the dentition. A total of 29 premolar roots of six mongrel dogs were extracted and instrumented with rotary nickel titanium files. Fifteen of these roots were then filled with a calcium hydroxide (Ca(OH)2) slurry and 14 roots were filled with Ledermix Paste paste. All accesses were sealed with glass ionomer and the roots replanted after an extraoral dry time of 60 min. After 4 months, the dogs were killed and the roots prepared for histological evaluation. Five-micrometer thick cross-sections of the root and surrounding tissue taken every 90 micro m were evaluated for healing. In addition, residual root mass was also measured to determine the extent of root structure loss for each treatment method. The Ledermix Paste-treated roots had statistically significantly more healing and less resorption than the roots treated with Ca(OH)2. Root filling with Ledermix Paste also resulted in significantly less loss in root mass due to resorption compared to those roots filled with Ca(OH)2. Immediate intracanal placement of Ledermix Paste at the emergency visit after an avulsion injury appears to decrease resorption and increase favorable healing.
利德美混合糊剂是一种含有曲安奈德和地美环素的糊剂，具有抗炎活性，可能会减缓牙列严重创伤后的吸收过程。从6只杂种犬中拔出29颗前磨牙牙根，并用旋转镍钛锉进行根管预备。其中15颗牙根用氢氧化钙（Ca(OH)₂）糊剂充填，14颗牙根用利德美混合糊剂充填。所有根管口均用玻璃离子封闭，牙根在口外干燥60分钟后再植入。4个月后，处死犬只，对牙根进行组织学评估。每隔90μm取5μm厚的牙根及周围组织横断面，评估愈合情况。此外，还测量了剩余牙根质量，以确定每种治疗方法的牙根结构丧失程度。与用Ca(OH)₂治疗的牙根相比，用利德美混合糊剂治疗的牙根在统计学上愈合更多，吸收更少。与用Ca(OH)₂充填的牙根相比，用利德美混合糊剂进行根管充填导致的牙根吸收造成的牙根质量损失也显著更少。在牙脱位损伤后的急诊就诊时立即将利德美混合糊剂置于根管内，似乎可以减少吸收并增加良好的愈合。
