Department of Textile Engineering, Chonbuk National Univiversity, Jeonju, South Korea.
J Nanobiotechnology. 2008 Jan 4;6:1. doi: 10.1186/1477-3155-6-1.
This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37 degrees C. Nearly 8.53 +/- 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.
本项目涉及 N-己酰化壳聚糖或简单修饰壳聚糖（MC）稳定的氧化铁纳米粒子（MC-IOPs）的合成以及 MC-IOPs 的生物学评价。使用常规方法制备含有 MC 的 IOPs，并使用小鼠巨噬细胞系（RAW 细胞）评估细胞摄取的程度。发现 MC-IOPs 与 RAW 细胞迅速结合，并且在 37°C 孵育 24 小时内通常达到饱和。在饱和时，每个细胞结合或内化的铁约为 8.53 +/- 0.31 pg。根据这些结果，我们得出结论，MC-IOPs 可有效地递送至 RAW 细胞中，我们还希望 MC-IOPs 可用于生物医学领域的 MRI 增强剂。
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