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年轻士兵血清胆固醇和白蛋白水平较低与社区获得性肺炎风险

Low levels of serum cholesterol and albumin and the risk of community-acquired pneumonia in young soldiers.

作者信息

Kang D R, Kim Y K, Park M S, Kim Y S, Ko D H, Kim C

机构信息

Department of Preventive Medicine, Yonsei University College of Medicine, Seodaemun-Gu, Seoul, Korea.

出版信息

Int J Tuberc Lung Dis. 2008 Jan;12(1):26-32.

PMID:18173873
Abstract

SETTING

The risk factors of community-acquired pneumonia (CAP) in high-risk groups have been examined in many studies. Such studies, however, have limited application for young people in special environments.

OBJECTIVE

To study the risk factors of CAP in young soldiers.

DESIGN

A hospital-based case-control study was carried out during the two winters between 2003 and 2005. A total of 255 CAP cases aged 18-23 years were enrolled and were matched by age and date of hospitalisation with 255 controls.

RESULTS

All CAP cases and 148 controls (58.0%) were military trainees. Most cases (96.1%) were non-severe CAP (pneumonia severity index risk class 1). Serum levels of total cholesterol, albumin, total protein and body mass index (BMI) were lower in CAP cases than in controls. In conditional logistic regression analysis, an increased risk of CAP was independently associated with military trainees, low levels of cholesterol and albumin. However, low BMI (<18.5 kg/m(2)) was not found to be associated with the risk of CAP after adjusting for other factors.

CONCLUSION

In Korea, the risk of CAP is significantly high in military trainees, with low levels of cholesterol and albumin being associated with the development of CAP in young soldiers.

摘要

背景

许多研究已对高危人群社区获得性肺炎(CAP)的危险因素进行了调查。然而,此类研究在特殊环境中的年轻人中应用有限。

目的

研究年轻士兵患CAP的危险因素。

设计

在2003年至2005年期间的两个冬季开展了一项基于医院的病例对照研究。共纳入255例年龄在18 - 23岁的CAP病例,并按年龄和住院日期与255例对照进行匹配。

结果

所有CAP病例和148例对照(58.0%)为军事训练学员。大多数病例(96.1%)为非重症CAP(肺炎严重程度指数风险等级1)。CAP病例的血清总胆固醇、白蛋白、总蛋白水平及体重指数(BMI)均低于对照。在条件logistic回归分析中,CAP风险增加与军事训练学员、低胆固醇水平和低白蛋白水平独立相关。然而,在调整其他因素后,低BMI(<18.5 kg/m²)未被发现与CAP风险相关。

结论

在韩国,军事训练学员患CAP的风险显著较高,低胆固醇水平和低白蛋白水平与年轻士兵患CAP有关。

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