Míguez María José, Rosenberg Rhonda, Burbano Ximena, Malow Robert
Associate Professor, School of Integrated Sciences and Humanity, Florida International University, Miami, FL, USA.
J AIDS Clin Res. 2011 Oct 21;Suppl 1(1). doi: 10.4172/2155-6113.S1-001.
We analyzed the role of cholesterol as a potential mediator of alcohol-increased risk of respiratory infections that required hospitalization in People Living with HIV (PLWH). Using a longitudinal clinic-based design, 346 PLWH were consecutively admitted and followed at Jackson Memorial Medical Center(enrolled in the study). Following national guidelines, PLWH were stratified according to cholesterol levels: <150 mg/dl (Hypocholesterolemia= HypoCHL), 151-200, and >200 mg/dl Hypercholesterolemia =HyperCHL), and compared on the basis of clinical outcomes, lymphocyte phenotypes and behavioral risks. Analyses indicated that compared to HyperCHL participants, HypoCHL subjects were more likely to be hospitalized, particularly for lower respiratory tract infections (LRTI). Excessive admissions were associated with more deviant lymphocyte profiles, particularly limited NK cells. In logistic regression analyses, smoking (OR=1.5), HypoCHL (OR=7.7), and alcohol (OR=1.2) were predictors of LRTI. These findings warrant further investigation of the potential use of HypoCHL as a risk marker, and the cost-effectiveness of switching prevention gears towards HypoCHL, alcohol and tobacco in PLWH.
我们分析了胆固醇作为酒精增加艾滋病毒感染者（PLWH）因呼吸道感染而需住院风险的潜在介导因素的作用。采用基于门诊的纵向设计，在杰克逊纪念医学中心连续收治并随访了346名PLWH（纳入研究）。按照国家指南，根据胆固醇水平对PLWH进行分层：<150 mg/dl（低胆固醇血症=低CHL）、151 - 200以及>200 mg/dl（高胆固醇血症=高CHL），并基于临床结局、淋巴细胞表型和行为风险进行比较。分析表明，与高CHL参与者相比，低CHL受试者更有可能住院，尤其是因下呼吸道感染（LRTI）。过多的住院与更异常的淋巴细胞谱相关，特别是自然杀伤细胞受限。在逻辑回归分析中，吸烟（OR = 1.5）、低CHL（OR = 7.7）和酒精（OR = 1.2）是LRTI的预测因素。这些发现值得进一步研究将低CHL作为风险标志物的潜在用途，以及在PLWH中针对低CHL、酒精和烟草调整预防措施的成本效益。
