Ahmed S Faisal, Wong Jarod S C, McGrogan Paraic
Bone & Endocrine Research Group, University of Glasgow, Glasgow, UK.
Horm Res. 2007;68 Suppl 5:117-21. doi: 10.1159/000110604. Epub 2007 Dec 10.
Growth in children with inflammatory bowel disease (IBD) is affected through a number of mechanisms; controlling disease activity and supporting poor nutritional status are paramount in these patients. Further understanding of the basic mechanisms by which cytokines influence growth will facilitate the development of therapeutic modalities to improve growth.
Clinical management that addresses growth and puberty in children with IBD should be a partnership between paediatric gastroenterologists and endocrinologists. Well-designed studies of growth-promoting hormonal treatment may answer questions regarding the efficacy and safety of treating growth retardation in the subgroup of patients who continue to fail to grow despite optimal management of their IBD.
炎症性肠病（IBD）患儿的生长受多种机制影响；控制疾病活动和改善营养不良状况对这些患儿至关重要。进一步了解细胞因子影响生长的基本机制将有助于开发促进生长的治疗方法。
针对IBD患儿生长和青春期问题的临床管理应由儿科胃肠病学家和内分泌学家共同协作。精心设计的促生长激素治疗研究可能会解答关于在IBD得到最佳管理但仍生长迟缓的亚组患者中治疗生长迟缓的疗效和安全性问题。
