Kalil Célia Luiza Petersen Vitello, Fachinello Fernanda Zatti, Lamb Flávia Maria, Comunello Luciane Nardi
Dermatology Department, Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil.
Skinmed. 2008 Jan-Feb;7(1):10-4. doi: 10.1111/j.1540-9740.2007.07145.x.
Many drugs are being used for prevention and treatment of photoaging, especially topical retinoids. The use of systemic retinoids, more specifically, isotretinoin, for this purpose has not been properly addressed to date. Our study was designed to assess the systemic use of isotretinoin used alone for the therapy of cutaneous photoaging.
To demonstrate that isotretinoin is converted into retinoid and improves the appearance of the photoaged skin.
Fifty women aged 40 to 60 years, phototype I, II, or III according Fitzpatrick, were selected to receive 20 mg of isotretinoin orally 3 times a week for a 3-month period. Patients underwent clinical and laboratory evaluation. Two biopsies and photographic control were performed. Patients were requested to use only topical photoprotecting agents during the treatment. Improvement in photoaging clinical parameters were evaluated through pictures taken and also through an evaluation form. Anatomopathologic parameters were obtained by comparing collagen degeneration and skin trophism. Results. Thirty patients fully complied with study requirements and were adequately analyzed. From the anatomopathologic data, an improvement of photoaging in 20 patients was observed.
Isotretinoin improves photoaging with few adverse events because of the low dose used and to the short treatment duration.
许多药物被用于预防和治疗光老化，尤其是局部用维甲酸类药物。迄今为止，系统性维甲酸类药物，更具体地说是异维甲酸，用于此目的尚未得到恰当的研究。我们的研究旨在评估单独使用异维甲酸全身治疗皮肤光老化的效果。
证明异维甲酸可转化为维甲酸并改善光老化皮肤的外观。
选择50名年龄在40至60岁之间、根据菲茨帕特里克分类法为I型、II型或III型皮肤的女性，每周口服3次20毫克异维甲酸，为期3个月。患者接受临床和实验室评估。进行了两次活检和拍照对照。治疗期间要求患者仅使用局部光保护剂。通过拍摄的照片以及一份评估表来评估光老化临床参数的改善情况。通过比较胶原退变和皮肤营养状况获得解剖病理学参数。结果：30名患者完全符合研究要求并得到充分分析。从解剖病理学数据来看，观察到20名患者的光老化情况有所改善。
由于使用剂量低且治疗持续时间短，异维甲酸改善光老化的同时不良事件较少。
