Magacho-Vieira Fabiano Nadson, Dias Gilmasa Daniele Rios
Magacho Institute for Health Education, Fortaleza, Ceará, Brazil.
Department of Clinical, Aesthetic and Surgical Dermatology, Batista Memorial Hospital, Fortaleza, Ceará, Brazil.
J Cosmet Dermatol. 2025 Aug;24(8):e70401. doi: 10.1111/jocd.70401.
Low-dose oral isotretinoin is increasingly used off-label for photoaging, with evidence of clinical and histologic skin improvement.
To review ocular risks associated with isotretinoin in aesthetic use and propose monitoring recommendations.
A narrative review of clinical studies, observational data, and mechanistic reports addressing isotretinoin-induced ocular effects was performed, integrating dermatologic and ophthalmologic perspectives.
Reported adverse effects include dry eye disease, meibomian gland dysfunction, and, rarely, retinal alterations. Risk may be cumulative in long-term or repeated cosmetic regimens.
A risk-adapted monitoring approach, emphasizing patient selection, informed consent, and interdisciplinary care, is recommended to balance cosmetic benefits with ocular safety.
低剂量口服异维A酸越来越多地被用于光老化的非适应证治疗，有临床和组织学上皮肤改善的证据。
综述异维A酸在美容用途中的眼部风险并提出监测建议。
对涉及异维A酸所致眼部效应的临床研究、观察性数据和机制报告进行叙述性综述，整合皮肤科和眼科观点。
报告的不良反应包括干眼症、睑板腺功能障碍以及罕见的视网膜改变。在长期或重复的美容方案中风险可能会累积。
建议采用一种根据风险调整的监测方法，强调患者选择、知情同意和跨学科护理，以平衡美容益处与眼部安全性。
