Cohen Sara I, Duong Thao T
Division of Physical Medicine and Rehabilitation, Department of Orthopedic Surgery, Stanford University, California, USA.
Am J Phys Med Rehabil. 2008 Mar;87(3):229-31. doi: 10.1097/PHM.0b013e318161971b.
A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mos after injury resulted in a dramatic increase in the level of alertness, including improved speech and gait. When the patient was not able to receive zolpidem for a brief period, the patient's lethargy returned, and he became bedbound until the medication was resumed.
一名35岁男性因心脏骤停导致缺氧性脑损伤，随后出现极度嗜睡且对刺激无反应。为提高患者的觉醒水平，尝试使用了多种药物，但患者的嗜睡症状并未改善。受伤8个月后，每天两次服用唑吡坦，患者的警觉性显著提高，言语和步态也有所改善。当患者短时间内无法服用唑吡坦时，嗜睡症状复发，只能卧床，直到重新开始用药。
