使用唑吡坦改善颅内占位性病变患者的觉醒和运动功能：一例报告

Improved Arousal and Motor Function Using Zolpidem in a Patient With Space-Occupying Intracranial Lesions: A Case Report.

作者信息

Bomalaski Martin Nicholas, Smith Sean Robinson

机构信息

Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E. Eisenhower Pkwy, Ste 100, Ann Arbor, MI 48108(∗).

Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI(†).

出版信息

PM R. 2017 Aug;9(8):831-833. doi: 10.1016/j.pmrj.2016.12.011. Epub 2017 Jan 16.

DOI:10.1016/j.pmrj.2016.12.011

PMID:28093373

Abstract

UNLABELLED

Patients with disorders of consciousness (DOC) have profound functional limitations with few treatment options for improving arousal and quality of life. Zolpidem is a nonbenzodiazepine hypnotic used to treat insomnia that has also been observed to paradoxically improve arousal in those with DOC, such as the vegetative or minimally conscious states. Little information exists on its use in patients with DOC who have intracranial space-occupying lesions. We present a case of a 24-year-old man in a minimally conscious state due to central nervous system lymphoma who was observed to have increased arousal and improved motor function after the administration of zolpidem.

LEVEL OF EVIDENCE

摘要

未标注

意识障碍（DOC）患者存在严重的功能限制，改善觉醒和生活质量的治疗选择很少。唑吡坦是一种用于治疗失眠的非苯二氮䓬类催眠药，也被观察到可反常地改善DOC患者（如植物状态或最低意识状态患者）的觉醒。关于其在患有颅内占位性病变的DOC患者中的应用信息很少。我们报告一例24岁因中枢神经系统淋巴瘤处于最低意识状态的男性患者，在服用唑吡坦后觉醒增加且运动功能改善。