急性丙型肝炎病毒感染患者进行肝活检的必要性。
The need for liver biopsy in a patient with acute HCV infection.
作者信息
Tsuang Wayne, Subramanian Ram, Liu Qiang, Hart John, Mohanty Smruti R
机构信息
Pritzker School of Medicine, Center for Liver Diseases, Section of Gastroenterology, Department of Medicine, University of Chicago, IL 60637, USA.
出版信息
Nat Clin Pract Gastroenterol Hepatol. 2008 Jan;5(1):54-7. doi: 10.1038/ncpgasthep1030.
BACKGROUND
A 45-year-old white female was admitted to hospital with a 1-week history of right upper quadrant abdominal pain, progressive tiredness and jaundice. Physical examination confirmed jaundice and revealed mild epigastric tenderness. Laboratory test results revealed an extremely elevated alanine aminotransferase concentration, a high bilirubin concentration, the presence of HCV RNA, and a significantly elevated antinuclear antibody titer.
INVESTIGATIONS
History and physical examination, laboratory investigations (including complete blood counts, liver function tests, electrolyte analysis, serological and genetic tests), Doppler ultrasound and CT scan of the abdomen, and liver biopsy.
DIAGNOSIS
Acute infection with HCV genotype 1a.
MANAGEMENT
Supportive care, which included monitoring vital signs and laboratory test results, and management of acute symptoms.
背景
一名45岁的白人女性因右上腹腹痛1周、进行性疲劳和黄疸入院。体格检查证实有黄疸，并发现上腹部轻度压痛。实验室检查结果显示丙氨酸转氨酶浓度极高、胆红素浓度高、存在丙型肝炎病毒RNA以及抗核抗体滴度显著升高。
检查
病史和体格检查、实验室检查（包括全血细胞计数、肝功能检查、电解质分析、血清学和基因检测）、腹部多普勒超声和CT扫描以及肝活检。
诊断
急性丙型肝炎病毒1a型感染。
治疗
支持性护理，包括监测生命体征和实验室检查结果以及处理急性症状。
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