Cheruku Pradeep, Paptchikhine Alexander, Ali Muhammad, Neudörfl Jörg-M, Andersson Pher G
Department of Biochemistry and Organic Chemistry, Box 576, 75123, Uppsala University, Sweden.
Org Biomol Chem. 2008 Jan 21;6(2):366-73. doi: 10.1039/b714744a. Epub 2007 Dec 4.
New thiazole-based chiral N,P-ligands that are open-chain analogues of known cyclic thiazole ligands have been synthesized and evaluated in the iridium-catalyzed asymmetric hydrogenation of trisubstituted olefins. Chirality was introduced into the ligands through a highly diastereoselective alkylation using Oppolzer's camphorsultam as chiral auxiliary. In general, the new catalysts are as reactive and selective as their cyclic counterparts for the asymmetric hydrogenation of various trisubstituted olefins.
新型基于噻唑的手性N,P-配体已被合成，它们是已知环状噻唑配体的开链类似物，并在铱催化的三取代烯烃不对称氢化反应中进行了评估。通过使用Oppolzer的樟脑磺内酰胺作为手性助剂的高度非对映选择性烷基化反应，将手性引入到配体中。一般来说，对于各种三取代烯烃的不对称氢化反应，新型催化剂与其环状对应物具有相同的反应活性和选择性。
