Khumsubdee Sakunchai, Burgess Kevin
Department of Chemistry, Box 30012, Texas A & M University, College Station, TX 77841-3012, USA.
ACS Catal. 2013 Feb 1;3(2):237-249. doi: 10.1021/cs3007389.
As methodology development matures it can be difficult to discern the most effective ways of performing certain transformations from the rest. This review summarizes the most important contributions leading to asymmetric hydrogenations of simple unsaturated-acid and ester substrates, with the objective of highlighting at least the best types of catalysts for each. Achievements in the area are described and these reveal situations where further efforts should be worthwhile, and ones where more research is only likely to give diminishing returns. In general, our conclusions are that the most useful types of catalysts for unsaturated-acids and -esters tend to be somewhat different, simple substrates have been studied extensively, and the field is poised to address more complex reactions. These could be ones involving alternative, particularly cyclic, structures, chemoselectivity issues, and more complex substrate stereochemistries.
随着方法学的发展逐渐成熟，从其他方法中辨别出执行某些转化的最有效方法可能会变得困难。本综述总结了导致简单不饱和酸和酯底物不对称氢化的最重要贡献，目的是至少突出每种底物的最佳催化剂类型。描述了该领域的成就，这些成就揭示了哪些情况下进一步的努力可能是值得的，以及哪些情况下更多的研究可能只会带来递减的回报。总体而言，我们的结论是，用于不饱和酸和酯的最有用的催化剂类型往往有所不同，简单底物已得到广泛研究，并且该领域已准备好应对更复杂的反应。这些反应可能涉及替代结构，特别是环状结构、化学选择性问题以及更复杂的底物立体化学。
