Fogarty Andrew W, Glancy Caoimhe, Jones Stuart, Lewis Sarah A, McKeever Tricia M, Britton John R
Division of Epidemiology and Public Health, University of Nottingham, and the Department of Clinical Chemistry, Nottingham City Hospital, Nottingham, United Kingdom.
Am J Clin Nutr. 2008 Jan;87(1):30-5. doi: 10.1093/ajcn/87.1.30.
An increase in weight is a risk factor for cardiovascular disease and cancer. This increased risk may be mediated by inflammation, but no long-term data are available on the effect of weight gain on systemic inflammation.
We tested the hypothesis that weight gain is associated with an increase in systemic inflammation during a 9-y period.
In 1991 data on body weight and a blood sample were collected from a random sample of 2425 randomly selected adults from a community-based cohort in Nottingham, United Kingdom. In 2000, these measures were repeated in 1301 of these participants. The main outcome measure was change in systemic inflammation as measured by serum C-reactive protein (CRP) from the 1222 participants who provided paired samples.
The mean change in weight from 1991 to 2000 was 2.9 kg (95% CI: 2.6, 3.2 kg). The geometric mean of CRP in 1991 was 1.22 mg/L (95% CI: 0.03, 125.0 mg/L), and it increased to 1.76 mg/L (95% CI: 0.09, 62.0 mg/L) in 2000 (P<0.001). A linear association was observed between increase in weight and serum CRP, with a 1-kg increment in weight being associated with an additional increase in CRP of 0.09 mg/L (95% CI: 0.02, 0.16 mg/L) during this time period.
During a 9-y period, an increase in weight is associated with an increase in systemic inflammation. This provides a mechanism that may explain some of the previously reported association of weight gain with an increased risk of both cancer and cardiovascular disease.
体重增加是心血管疾病和癌症的一个风险因素。这种风险增加可能由炎症介导，但关于体重增加对全身炎症影响的长期数据尚不可得。
我们检验了这样一个假设，即在9年期间体重增加与全身炎症增加相关。
1991年，从英国诺丁汉一个基于社区的队列中随机抽取2425名成年人，收集其体重数据和血样。2000年，对其中1301名参与者重复这些测量。主要结局指标是1222名提供配对样本的参与者血清C反应蛋白（CRP）所测量的全身炎症变化。
1991年至2000年体重的平均变化为2.9千克（95%置信区间：2.6，3.2千克）。1991年CRP的几何均值为1.22毫克/升（95%置信区间：0.03，125.0毫克/升），2000年增至1.76毫克/升（95%置信区间：0.09，62.0毫克/升）（P<0.001）。观察到体重增加与血清CRP之间存在线性关联，在此期间体重每增加1千克，CRP额外增加0.09毫克/升（95%置信区间：0.02，0.16毫克/升）。
在9年期间，体重增加与全身炎症增加相关。这提供了一种机制，可能解释了先前报道的体重增加与癌症和心血管疾病风险增加之间的一些关联。
