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Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines.

作者信息

Alvero Ayesha B, Montagna Michele K, Mor Gil

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

出版信息

Methods Mol Biol. 2008;414:79-82. doi: 10.1007/978-1-59745-339-4_7.

DOI:10.1007/978-1-59745-339-4_7
PMID:18175813
Abstract

The immediate assessment of response to therapy is most beneficial to ovarian cancer patients. This study shows the correlation of drug-induced caspase activation determined by western blot analysis and by Caspase-Glotrade mark assay. Our findings demonstrate that the use of the Caspase-Glotrade mark assay allows a simple, fast, and sensitive alternative for the evaluation of in vitro response to chemotherapy.

摘要

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