Vasadze L, Petriashvili E, Museliani T, Nikolaishvili M, Djariashvili T
Center of Radiobiology and Radiation Ecology.
Georgian Med News. 2007 Nov(152):45-7.
Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency to an increase of the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation. It is generally accepted that ACTH fragments activate limbic syctem and regulate instinctive - motivated behavior. The neuroactive properties of short fragments of ACTH (4-7) are considered to be the peptides of memory and behavior. The aim of the study was to investigate the influence of ACTH fragments on aggressive behavior of naturally aggressive rats. Two-fold intraperitoneal introduction of ACTH fragments provoke a change in the animals behavior -rats become non-agressive. Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency of increase the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation. The results obtained enable to conclude that fragment 4-7 of ACTH has an influence on aggressive behavior.
神经化学实验表明，大脑半球中氨基酸的代谢呈现出天冬氨酸与牛磺酸及γ-氨基丁酸的比例增加，同时氧化作用增强的趋势。人们普遍认为促肾上腺皮质激素片段会激活边缘系统并调节本能驱动行为。促肾上腺皮质激素（4-7）短片段的神经活性特性被认为是记忆和行为的肽类。该研究的目的是调查促肾上腺皮质激素片段对天生具有攻击性的大鼠攻击行为的影响。腹腔注射两次促肾上腺皮质激素片段会引起动物行为的改变——大鼠变得不再具有攻击性。神经化学实验表明，大脑半球中氨基酸的代谢有增加天冬氨酸与牛磺酸及γ-氨基丁酸比例的趋势，同时氧化作用增强。所获得的结果使我们能够得出结论，促肾上腺皮质激素的4-7片段对攻击行为有影响。
