Nakagawa H, Nihonmatsu N, Ohta S, Hirobe M
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biochem Biophys Res Commun. 1996 Aug 23;225(3):1027-34. doi: 10.1006/bbrc.1996.1289.
Several 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids were synthesized and found to have a transiently increasing effect on the locomotor activity of mice after peripheral injection. Three of the active compounds were detected in the brain after intraperitoneal administration. Two of them, the 7-hydroxy and 7-hydroxy-6-methoxy derivatives, were found as endogenous compounds in untreated rat brain and may play a physiological role. The effects of some of these compounds on the level of various endogenous amines, amino acids and metabolites were examined.
合成了几种1,2,3,4-四氢异喹啉-3-羧酸，发现外周注射后它们对小鼠的运动活性有短暂增强作用。腹腔给药后在大脑中检测到三种活性化合物。其中两种，即7-羟基和7-羟基-6-甲氧基衍生物，在未处理的大鼠大脑中作为内源性化合物被发现，可能发挥生理作用。研究了其中一些化合物对各种内源性胺、氨基酸和代谢物水平的影响。
