Shini Mohanad, Rubinsky Boris
Center for Bioengineering, Service of Humanity and Society, School of Engineering and Computer Science, Hebrew University of Jerusalem, Givat Ram Campus, Jerusalem, Israel.
Physiol Meas. 2008 Jan;29(1):109-26. doi: 10.1088/0967-3334/29/1/008. Epub 2008 Jan 3.
Biopsies are a reliable method for examining tissues and organs inside the body, in particular for detection of tumors. However, a single biopsy produces only limited information on the site from which it is taken. Therefore, tumor detection now employs multiple biopsy samplings to examine larger volumes of tissue. Nevertheless, even with multiple biopsies, the information remains discrete, while the costs of biopsy increase. Here we propose and evaluate the feasibility of using minimally invasive medical imaging as a means to overcome the limitations of discrete biopsy sampling. The minimally invasive medical imaging technique employs the biopsy probe as electrodes for measurements of electrical impedance tomography relevant data during each biopsy sampling. The data from multiple samplings are combined and used to produce an EIT image of the tissue. Two- and three-dimensional mathematical simulations confirm that the minimally invasive medical imaging technique can produce electrical impedance tomography images of the tissues between the biopsy probe insertion sites. We show that these images can detect tumors that would be missed with multiple biopsy samplings only, and that the technique may facilitate the detection of tumors with fewer biopsies, thereby reducing the cost of cancer detection.
活检是检查体内组织和器官的可靠方法，尤其适用于肿瘤检测。然而，单次活检只能从取样部位获取有限的信息。因此，目前肿瘤检测采用多次活检取样来检查更大体积的组织。尽管如此，即使进行多次活检，信息仍然是离散的，同时活检成本也会增加。在此，我们提出并评估使用微创医学成像作为克服离散活检取样局限性的一种手段的可行性。微创医学成像技术在每次活检取样期间，将活检探头用作电极来测量电阻抗断层扫描相关数据。来自多次取样的数据被合并并用于生成组织的电阻抗断层扫描图像。二维和三维数学模拟证实，微创医学成像技术可以生成活检探头插入部位之间组织的电阻抗断层扫描图像。我们表明，这些图像能够检测出仅通过多次活检取样会遗漏的肿瘤，并且该技术可能有助于减少活检次数来检测肿瘤，从而降低癌症检测成本。
