• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

牛乳铁蛋白对人成骨样细胞细胞外基质钙化的影响。

Effect of bovine lactoferrin on extracellular matrix calcification by human osteoblast-like cells.

作者信息

Takayama Yoshiharu, Mizumachi Koko

机构信息

Functional Biomolecules Research Team, National Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan.

出版信息

Biosci Biotechnol Biochem. 2008 Jan;72(1):226-30. doi: 10.1271/bbb.70465. Epub 2008 Jan 7.

DOI:10.1271/bbb.70465
PMID:18175916
Abstract

Osteoblast-mediated calcium deposition to the extracellular matrix (ECM) is a critical step in bone tissue generation. Bovine lactoferrin enhanced the calcium deposition by MG63 human osteoblast-like cells cultured on collagen-coated plates. Lactoferrin also promoted the alkaline phosphatase activity and osteocalcin production during the calcification process, whereas it had little effect on the growth of the cells on the collagen-coated plates.

摘要

成骨细胞介导的钙沉积到细胞外基质（ECM）是骨组织生成中的关键步骤。牛乳铁蛋白增强了在胶原包被平板上培养的MG63人成骨样细胞的钙沉积。乳铁蛋白在钙化过程中还促进了碱性磷酸酶活性和骨钙素的产生，而对胶原包被平板上细胞的生长影响很小。

相似文献

1
Effect of bovine lactoferrin on extracellular matrix calcification by human osteoblast-like cells.牛乳铁蛋白对人成骨样细胞细胞外基质钙化的影响。
Biosci Biotechnol Biochem. 2008 Jan;72(1):226-30. doi: 10.1271/bbb.70465. Epub 2008 Jan 7.
2
Effect of lactoferrin-embedded collagen membrane on osteogenic differentiation of human osteoblast-like cells.乳铁蛋白包埋胶原膜对人成骨样细胞成骨分化的影响。
J Biosci Bioeng. 2009 Feb;107(2):191-5. doi: 10.1016/j.jbiosc.2008.09.018.
3
Contribution of osteocalcin-mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells.骨钙素模拟肽促进人成骨样细胞的成骨活性和细胞外基质矿化。
Colloids Surf B Biointerfaces. 2019 Jan 1;173:662-671. doi: 10.1016/j.colsurfb.2018.10.035. Epub 2018 Oct 17.
4
The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization.I型胶原蛋白对原代和传代大鼠颅骨成骨细胞成骨细胞表型发育和维持的影响：支持细胞生长、粘附和细胞外基质矿化的基因表达的改变
Exp Cell Res. 1995 Jan;216(1):35-45. doi: 10.1006/excr.1995.1005.
5
L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro.左旋肉碱和富马酸异戊酰左旋肉碱在体外对人成骨细胞的增殖和分化有积极影响。
Calcif Tissue Int. 2005 Jun;76(6):458-65. doi: 10.1007/s00223-004-0147-4. Epub 2005 May 19.
6
Zinc deprivation inhibits extracellular matrix calcification through decreased synthesis of matrix proteins in osteoblasts.缺锌通过减少成骨细胞中细胞外基质蛋白的合成来抑制细胞外基质钙化。
Mol Nutr Food Res. 2011 Oct;55(10):1552-60. doi: 10.1002/mnfr.201000659. Epub 2011 Jun 8.
7
Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development.培养的小鼠MC3T3-E1细胞不同的增殖和分化阶段：成骨细胞发育的体外模型
J Bone Miner Res. 1992 Jun;7(6):683-92. doi: 10.1002/jbmr.5650070613.
8
Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells.猪胎儿釉基质衍生物刺激前成骨细胞2T9细胞增殖但不促进其分化，抑制成骨样MG63细胞增殖并促进其分化，还能增加正常人成骨细胞NHOst细胞的增殖和分化。
J Periodontol. 2000 Aug;71(8):1287-96. doi: 10.1902/jop.2000.71.8.1287.
9
[Cell mediated calcification in three-dimensional collagen gel culture of the osteoblast-like cells derived from rat calvaria].[大鼠颅骨来源的成骨样细胞在三维胶原凝胶培养中的细胞介导钙化]
Nihon Seikeigeka Gakkai Zasshi. 1993 Oct;67(10):963-76.
10
A potent 1,4-dihydropyridine L-type calcium channel blocker, benidipine, promotes osteoblast differentiation.强效1,4 - 二氢吡啶类L型钙通道阻滞剂贝尼地平可促进成骨细胞分化。
Calcif Tissue Int. 2002 Jan;70(1):30-9. doi: 10.1007/s00223-001-1010-5. Epub 2001 Dec 21.

引用本文的文献

1
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.LTF 通过抑制 JAK2/STAT3 通路抑制软骨终板的钙化、衰老和基质降解，从而改善软骨终板退变。
J Cell Mol Med. 2024 Oct;28(19):e18267. doi: 10.1111/jcmm.18267.
2
Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials for Enhanced Osteo-Differentiation Ability.用于增强骨分化能力的乳铁蛋白锚定的鞣酸修饰介孔二氧化硅纳米材料
Pharmaceutics. 2020 Dec 26;13(1):30. doi: 10.3390/pharmaceutics13010030.
3
Comparison of the Anabolic Effects of Reported Osteogenic Compounds on Human Mesenchymal Progenitor-derived Osteoblasts.
已报道的成骨化合物对人骨髓间充质祖细胞来源的成骨细胞的合成代谢作用比较。
Bioengineering (Basel). 2020 Jan 21;7(1):12. doi: 10.3390/bioengineering7010012.
4
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings.人骨髓间充质干细胞对乳铁蛋白基复合涂层的反应。
Materials (Basel). 2019 Oct 18;12(20):3414. doi: 10.3390/ma12203414.
5
Lactoferrin promote primary rat osteoblast proliferation and differentiation via up-regulation of insulin-like growth factor-1 expression.乳铁蛋白通过上调胰岛素样生长因子-1的表达促进原代大鼠成骨细胞的增殖和分化。
Mol Biol Rep. 2014 Aug;41(8):5019-30. doi: 10.1007/s11033-014-3368-2. Epub 2014 May 3.
6
Effect of lactoferrin on osteogenic differentiation of human adipose stem cells.乳铁蛋白对人脂肪干细胞成骨分化的影响。
Int Orthop. 2012 Mar;36(3):647-53. doi: 10.1007/s00264-011-1303-x. Epub 2011 Jun 29.