Ohara Jiro, Togari Tetsuro, Kurokawa Aya, Maeda Junko, Ishiguro Naotaka, Furuoka Hidefumi, Horiuchi Motohiro
Laboratory of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Med Sci. 2007 Dec;69(12):1325-9. doi: 10.1292/jvms.69.1325.
The selection of sheep with scrapie-resistant PrP genotypes is one of the control measures for transmissible spongiform encephalopathies in ruminants. In this study, we investigated the frequencies of PrP genotypes in meat breeds in Japan. The nationwide surveillance revealed that nearly half of the Suffolk sheep, a major meat breed in Japan, carried scrapie-susceptible AQ/AQ and AQ/VQ genotypes. In addition, the VQ haplotype, which confers high susceptibility to scrapie within sheep, was also found in Poll Dorset sheep. A trial of selective breeding using sires with scrapie-resistant PrP genotypes AQ/AR and AR/AR could raise the ratio of scrapie-resistant sheep from less than 50% to 80% within 3 years. However, the use of sires with the AR/AR genotype and the selection of ewes would be required to achieve a higher ratio of scrapie-resistant sheep.
选择具有抗瘙痒病朊蛋白基因型的绵羊是反刍动物传染性海绵状脑病的控制措施之一。在本研究中，我们调查了日本肉用品种绵羊中朊蛋白基因型的频率。全国范围内的监测显示，日本主要肉用品种萨福克羊中，近一半携带易患瘙痒病的AQ/AQ和AQ/VQ基因型。此外，在波德代绵羊中也发现了在绵羊中对瘙痒病具有高易感性的VQ单倍型。使用具有抗瘙痒病朊蛋白基因型AQ/AR和AR/AR的种公羊进行选择性育种试验，可在3年内将抗瘙痒病绵羊的比例从不到50%提高到80%。然而，要实现更高比例的抗瘙痒病绵羊，则需要使用AR/AR基因型的种公羊并选择母羊。
