Merchant Roland C, Chee Kerlen J, Liu Tao, Mayer Kenneth H
Department of Emergency Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA.
J Acquir Immune Defic Syndr. 2008 Mar 1;47(3):358-68. doi: 10.1097/QAI.0b013e318160d599.
To compare the incidence and types of emergency department (ED) visits for blood or body fluid exposures sustained by health care workers (HCWs) in Rhode Island and to identify factors predictive of HIV postexposure prophylaxis (PEP) utilization for these exposures.
A retrospective study of ED visits for blood or body fluid exposures to all Rhode Island EDs from January 1995 to June 2001 was conducted. Average incidence rates (IRs) of visits by HCW occupation and type of exposure were estimated and compared. Logistic regression models were created to determine which HCWs were more likely to be offered and to accept HIV PEP.
Of 1551 HCW ED visits for occupational exposures, 72.5% sustained a percutaneous injury and only 2.5% were exposed to a source known to be HIV-infected. Hospital custodians had the highest IR of ED visits for percutaneous injuries (81 ED visits per year per 10,000 workers). Visits for all exposures increased over the study years and were most common during March, on weekends, and at 5:00 PM. Of all HCWs, 91.2% presented within 24 hours of their exposure and 98.2% presented within 72 hours. HIV PEP was offered to 469 HCWs and accepted 229 times. HCWs more likely to be offered HIV PEP were exposed to a known HIV-infected source (odds ratio [OR] = 6.38), sustained a significant exposure (OR = 4.98), presented to an academic hospital ED (OR = 2.60), were a member of the medical staff (OR = 2.02), and were exposed during the latter years of the study (OR = 1.23). HCWs were more likely to accept HIV PEP when it was offered if they were male (OR = 1.64) and presented to an academic hospital ED (OR = 2.72).
The IRs of ED visits for exposures varied by occupation, and there were clear temporal trends for these visits. Despite the existence of federal guidelines for HIV PEP for occupational blood or body fluid exposures, factors other than characteristics of the exposure, such as type of hospital, occupation, and gender, may be influencing HIV PEP utilization.
比较罗德岛医护人员(HCWs)因血液或体液暴露而到急诊科(ED)就诊的发生率和类型,并确定这些暴露后接受HIV暴露后预防(PEP)的预测因素。
对1995年1月至2001年6月罗德岛所有急诊科因血液或体液暴露而进行的ED就诊进行回顾性研究。估计并比较了按HCW职业和暴露类型划分的就诊平均发生率(IRs)。建立逻辑回归模型以确定哪些HCWs更有可能被提供并接受HIV PEP。
在1551例HCW因职业暴露而进行的ED就诊中,72.5%发生了经皮损伤,只有2.5%暴露于已知感染HIV的源。医院 custodians 经皮损伤的ED就诊IR最高(每10,000名工人每年81次ED就诊)。在研究期间,所有暴露的就诊次数都有所增加,在3月、周末和下午5点最为常见。在所有HCWs中,91.2%在暴露后24小时内就诊,98.2%在72小时内就诊。469名HCWs被提供了HIV PEP,229次被接受。更有可能被提供HIV PEP的HCWs暴露于已知感染HIV的源(优势比[OR]=6.38),发生了重大暴露(OR=4.98),到学术医院急诊科就诊(OR=2.60),是医务人员(OR=2.02),并且在研究的后几年暴露(OR=1.23)。如果HCWs是男性(OR=1.64)并且到学术医院急诊科就诊(OR=2.72),则他们在被提供HIV PEP时更有可能接受。
因暴露而到急诊科就诊的IRs因职业而异,并且这些就诊有明显的时间趋势。尽管存在关于职业血液或体液暴露后HIV PEP的联邦指南,但除暴露特征之外的因素,如医院类型、职业和性别,可能会影响HIV PEP的使用。