Rosenzweig-Lipson Sharon, Dunlop John, Marquis Karen L
Wyeth Discovery Neuroscience, Princeton, New Jersey 08543, USA.
Drug News Perspect. 2007 Nov;20(9):565-71. doi: 10.1358/dnp.2007.20.9.1162244.
Modulating activity at the 5-HT(2C) receptor holds a tremendous amount of therapeutic promise in multiple psychiatric indications. However, the signaling and regulation of the 5-HT(2C) receptor is highly complex due to multiple signaling pathways and agonist-directed trafficking of this receptor. Moreover, the 5-HT(2C) receptor is differentially regulated via RNA editing in multiple psychiatric disorders and following either pharmacological or environmental manipulation. Direct and indirect data suggest that both agonists and antagonists may provide benefits in several disorders. The current review highlights the underlying complexities of this area and provides the rationale for using 5-HT(2C) agonists in the treatment of both schizophrenia and depressive disorders.
调节5-羟色胺（5-HT）2C受体的活性在多种精神疾病适应症中具有巨大的治疗前景。然而，由于该受体存在多种信号通路和激动剂介导的转运，5-HT2C受体的信号传导和调节非常复杂。此外，在多种精神疾病以及药物或环境操纵后，5-HT2C受体通过RNA编辑受到不同的调节。直接和间接数据表明，激动剂和拮抗剂在几种疾病中可能都有益处。本综述强调了该领域潜在的复杂性，并为使用5-HT2C激动剂治疗精神分裂症和抑郁症提供了理论依据。
