Al-Khuwaitir Tarig S, Al-Zuhair Amin A, Al-Ghamdi Ali G, Khan Abdulaziz
Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2008 Jan;29(1):129-32.
Nalidixic acid-resistant Salmonella typhi NARST infections increase minimal inhibitory concentrations of fluoroquinolones, due to chromosomal mutations in the gene encoding DNA gyrase, and can lead to a delayed treatment response. This in turn alters the course of the disease allowing for a protracted period of illness and the occurrence of complications. In this case report, we present a patient from the Indian sub-continent, who was diagnosed with NARST complicated by sub-intestinal obstruction, her diagnosis, treatment, and subsequent recovery.
耐萘啶酸伤寒沙门氏菌（NARST）感染会增加氟喹诺酮类药物的最低抑菌浓度，这是由于编码DNA促旋酶的基因发生染色体突变所致，并且可能导致治疗反应延迟。这进而会改变疾病进程，导致病程延长并出现并发症。在本病例报告中，我们介绍了一位来自印度次大陆的患者，该患者被诊断为NARST感染并伴有小肠梗阻，报告了她的诊断、治疗及后续康复情况。
