一名感染了对萘啶酸耐药且对环丙沙星敏感性降低的肠炎沙门氏菌伤寒血清型的伤寒患者治疗失败：喀麦隆的一例病例报告。
Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon.
作者信息
Nkemngu Njinkeng J, Asonganyi Etienne D N, Njunda Anna L
机构信息
St. John's Maternity and Hospital, Fiango, Kumba, Cameroon.
出版信息
BMC Infect Dis. 2005 Jun 21;5:49. doi: 10.1186/1471-2334-5-49.
Abstract
BACKGROUND
Fluoroquinolones or third generation cephalosporins are the drugs of choice for the treatment of typhoid fever. Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon.
CASE PRESENTATION
A 29-year-old female patient with suspected typhoid fever from Kumba, Cameroon, yielded growth of Salmonella enterica serovar Typhi in blood culture. The isolate was resistant to nalidixic acid but sensitive to ciprofloxacin by disc diffusion test. However, the patient did not respond to treatment with ciprofloxacin, although the isolate was apparently susceptible to ciprofloxacin.
CONCLUSION
Treatment failure with ciprofloxacin in our case indicates the presence of nalidixic acid resistant S. enterica serovar Typhi (NARST) with reduced susceptibility to ciprofloxacin in Cameroon (Central Africa).
摘要
背景
氟喹诺酮类药物或第三代头孢菌素是治疗伤寒热的首选药物。在亚洲和欧洲，已有氟喹诺酮类药物治疗失败的报道。我们报告了喀麦隆一例伤寒热患者使用环丙沙星治疗失败的病例。
病例介绍
一名来自喀麦隆昆巴的29岁疑似伤寒热女性患者，血培养分离出肠炎沙门氏菌伤寒血清型。通过纸片扩散试验，该分离株对萘啶酸耐药，但对环丙沙星敏感。然而，尽管该分离株显然对环丙沙星敏感，但患者对环丙沙星治疗无反应。
结论
我们病例中环丙沙星治疗失败表明喀麦隆（中非）存在对萘啶酸耐药且对环丙沙星敏感性降低的肠炎沙门氏菌伤寒血清型（NARST）。
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