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J Clin Microbiol. 2004 Apr;42(4):1477-82. doi: 10.1128/JCM.42.4.1477-1482.2004.
2
Ciprofloxacin treatment failure in typhoid fever case, Pakistan.巴基斯坦伤寒病例中 ciprofloxacin（环丙沙星）治疗失败
Emerg Infect Dis. 2003 Dec;9(12):1621-2. doi: 10.3201/eid0912.030230.
3
Typhoid fever.伤寒热
N Engl J Med. 2002 Nov 28;347(22):1770-82. doi: 10.1056/NEJMra020201.
4
Intermediate susceptibility to ciprofloxacin in Salmonella typhi strains in India.印度伤寒沙门氏菌菌株对环丙沙星中度敏感。
Eur J Clin Microbiol Infect Dis. 2001 Oct;20(10):760-1. doi: 10.1007/s100960100603.
5
Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia.从东南亚返回的旅行者中肠炎沙门氏菌血清型对氟喹诺酮类药物敏感性降低。
Emerg Infect Dis. 2001 Nov-Dec;7(6):996-1003. doi: 10.3201/eid0706.010613.
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Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype typhi, United Kingdom.英国伤寒沙门氏菌肠炎血清型对环丙沙星的敏感性降低。
Emerg Infect Dis. 2001 May-Jun;7(3):448-50. doi: 10.3201/eid0703.010315.
7
Genotypic analysis of multidrug-resistant Salmonella enterica Serovar typhi, Kenya.肯尼亚多重耐药性伤寒沙门氏菌血清型的基因分型分析
Emerg Infect Dis. 2000 Nov-Dec;6(6):649-51. doi: 10.3201/eid0606.000616.
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A randomized controlled comparison of azithromycin and ofloxacin for treatment of multidrug-resistant or nalidixic acid-resistant enteric fever.阿奇霉素与氧氟沙星治疗多重耐药或耐萘啶酸肠热症的随机对照比较
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Detection of decreased fluoroquinolone susceptibility in Salmonellas and validation of nalidixic acid screening test.沙门氏菌中氟喹诺酮敏感性降低的检测及萘啶酸筛选试验的验证
J Clin Microbiol. 1999 Nov;37(11):3572-7. doi: 10.1128/JCM.37.11.3572-3577.1999.
10
Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment.越南耐喹诺酮伤寒沙门氏菌：耐药的分子基础及治疗的临床反应
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一名感染了对萘啶酸耐药且对环丙沙星敏感性降低的肠炎沙门氏菌伤寒血清型的伤寒患者治疗失败：喀麦隆的一例病例报告。

Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon.

作者信息

Nkemngu Njinkeng J, Asonganyi Etienne D N, Njunda Anna L

机构信息

St. John's Maternity and Hospital, Fiango, Kumba, Cameroon.

出版信息

BMC Infect Dis. 2005 Jun 21;5:49. doi: 10.1186/1471-2334-5-49.

DOI:10.1186/1471-2334-5-49
PMID:15969764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184073/
Abstract

BACKGROUND

Fluoroquinolones or third generation cephalosporins are the drugs of choice for the treatment of typhoid fever. Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon.

CASE PRESENTATION

A 29-year-old female patient with suspected typhoid fever from Kumba, Cameroon, yielded growth of Salmonella enterica serovar Typhi in blood culture. The isolate was resistant to nalidixic acid but sensitive to ciprofloxacin by disc diffusion test. However, the patient did not respond to treatment with ciprofloxacin, although the isolate was apparently susceptible to ciprofloxacin.

CONCLUSION

Treatment failure with ciprofloxacin in our case indicates the presence of nalidixic acid resistant S. enterica serovar Typhi (NARST) with reduced susceptibility to ciprofloxacin in Cameroon (Central Africa).

摘要

背景

氟喹诺酮类药物或第三代头孢菌素是治疗伤寒热的首选药物。在亚洲和欧洲，已有氟喹诺酮类药物治疗失败的报道。我们报告了喀麦隆一例伤寒热患者使用环丙沙星治疗失败的病例。

病例介绍

一名来自喀麦隆昆巴的29岁疑似伤寒热女性患者，血培养分离出肠炎沙门氏菌伤寒血清型。通过纸片扩散试验，该分离株对萘啶酸耐药，但对环丙沙星敏感。然而，尽管该分离株显然对环丙沙星敏感，但患者对环丙沙星治疗无反应。

结论

我们病例中环丙沙星治疗失败表明喀麦隆（中非）存在对萘啶酸耐药且对环丙沙星敏感性降低的肠炎沙门氏菌伤寒血清型（NARST）。