Piazzini Ada, Turner Katherine, Vignoli Aglaia, Canger Raffaele, Canevini Maria Paola
Epilepsy Center, St. Paolo Hospital, Milan, Italy.
Epilepsia. 2008 Apr;49(4):657-62. doi: 10.1111/j.1528-1167.2007.01482.x. Epub 2007 Dec 28.
The aim of the present study was to investigate the possible frontal cognitive dysfunction in patients with juvenile myoclonic epilepsy (JME) and to compare the results with those of patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), as well as with controls.
A total of 50 patients with JME, 40 patients with FLE, 40 patients with TLE, and 40 normal controls, all matched for age, education, and IQ, were administered tests to assess frontal functions (the Word Fluency Test and the Wisconsin Card Sorting Test [WCST]). All participants had a normal intelligence level based on the Wechsler Adult Intelligence Scale, and did not take medications other than antiepileptics (AEDs) or have a psychiatric history.
Patients with JME had severe impairment in all administered tasks, similar to that of patients with FLE; TLE patients and controls followed in order. Multiple regression analysis did not disclose any significant effect of clinical variables on the cognitive deficits.
These results clearly suggest that JME patients can show some frontal dysfunction, which may affect both epileptogenic features and cognitive processes. Further studies are needed to confirm these findings.
本研究旨在调查青少年肌阵挛性癫痫（JME）患者可能存在的额叶认知功能障碍，并将结果与额叶癫痫（FLE）、颞叶癫痫（TLE）患者以及对照组进行比较。
共有50例JME患者、40例FLE患者、40例TLE患者和40名正常对照者，所有受试者在年龄、教育程度和智商方面相匹配，接受了评估额叶功能的测试（词语流畅性测试和威斯康星卡片分类测试[WCST]）。所有参与者根据韦氏成人智力量表显示智力水平正常，且除抗癫痫药物（AEDs）外未服用其他药物，也没有精神病史。
JME患者在所有测试任务中均有严重损伤，与FLE患者相似；TLE患者和对照组依次次之。多元回归分析未发现临床变量对认知缺陷有任何显著影响。
这些结果清楚地表明，JME患者可能存在一些额叶功能障碍，这可能会影响致痫特征和认知过程。需要进一步研究来证实这些发现。
