Feyzioğlu Aynur, Midi İpek, Ayık Elif, Kaşıkçı Gizem Baki, Kaşıkçı Cengiz Han
University of Health Sciences, Hamidiye Institute of Health Sciences, Department of Clinical Psychology, İstanbul, Turkey.
Marmara University, Pendik Training and Research Hospital, Department of Neurology, İstanbul, Turkey.
Noro Psikiyatr Ars. 2023 May 17;60(2):129-133. doi: 10.29399/npa.28097. eCollection 2023.
Cognitive impairment often occurs secondary to epilepsy. This study aims to evaluate the cognitive functions of patients with idiopathic generalized epilepsy (IGE) by using the digital neuropsychological assessment.
Seventy-nine patients diagnosed with IGE in the last 10 years in our clinic, who completed at least eight years of education were recruited. Participants who met the criteria were 36 individuals with IGE syndrome as well as 36 healthy individuals between the ages of 18-48. All volunteer participants were administered the standardized mini mental test (SMMT) and the Beck depression scale (BDS). For the neurocognitive assessment, participants completed five tasks in TestMyBrain digital neuropsychology test battery (TMB) which are TMB digit span, TMB choice reaction time test, TMB visual paired associates test, TMB matrix reasoning, and TMB digit symbol matching assessing a variety of cognitive domains.
IGE patients showed lower cognitive performance in attention, short-term memory, working memory, visual memory, episodic memory, cognitive processing speed, response selection/inhibition, fluid cognitive ability, and perceptual reasoning domains. The results show that IGE patients have cognitive dysfunction in many cognitive domains.
IGE patients performed significantly worse outcomes in some tests of the TMB. In this study, it is aimed to emphasize the necessity of evaluating the cognitive aspects of epilepsy patients, which will be of great importance in their functionality, in addition to providing symptomatic treatment in order to control their seizures.
认知障碍常继发于癫痫。本研究旨在通过数字神经心理学评估来评价特发性全身性癫痫（IGE）患者的认知功能。
招募了在我们诊所过去10年中被诊断为IGE且完成至少8年教育的79名患者。符合标准的参与者包括36名IGE综合征患者以及36名年龄在18 - 48岁之间的健康个体。所有志愿者参与者均接受了标准化简易精神状态检查（SMMT）和贝克抑郁量表（BDS）测试。对于神经认知评估，参与者在TestMyBrain数字神经心理学测试组合（TMB）中完成了五项任务，即TMB数字广度测试、TMB选择反应时测试、TMB视觉配对联想学习测试、TMB矩阵推理测试以及TMB数字符号匹配测试，这些测试评估了多种认知领域。
IGE患者在注意力、短期记忆、工作记忆、视觉记忆、情景记忆、认知处理速度、反应选择/抑制、流体认知能力和知觉推理领域的认知表现较低。结果表明，IGE患者在许多认知领域存在认知功能障碍。
IGE患者在TMB的某些测试中表现明显较差。在本研究中，旨在强调评估癫痫患者认知方面的必要性除了为控制癫痫发作提供对症治疗外，这对其功能状态也非常重要。
