McCarey David, McInnes Iain B
Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow, Scotland, G31 2ER, UK.
Curr Rheumatol Rep. 2007 Dec;9(6):442-8. doi: 10.1007/s11926-007-0072-4.
Psoriatic arthritis is a common inflammatory arthropathy that occurs in approximately 25% of psoriasis patients. Due to significant advances in therapeutics--mainly the advent of biologic therapy--the disease has been subject to intense investigation recently. This review summarizes recent investigations of disease pathogenesis and clinical treatment. Clinical responses to tumor necrosis factor-blocking agents appear robust and superior to traditional disease-modifying drug responses, whereas other interventions, such as costimulation blockade, require more investigation. The pathogenesis of the disease appears related to T helper 17-polarized immune responses that target skin, joints, and the enthesial compartment. Finally, new insights into the disorder's genetic antecedents are emerging as more cohorts of patients undergo advanced genetic screening methods.
银屑病关节炎是一种常见的炎性关节病，约25%的银屑病患者会出现该病症。由于治疗方法取得了重大进展——主要是生物疗法的出现——近年来对该疾病的研究十分深入。这篇综述总结了近期关于疾病发病机制和临床治疗的研究。对肿瘤坏死因子阻断剂的临床反应似乎很显著，且优于传统的改善病情药物的反应，而其他干预措施，如共刺激阻断，还需要更多研究。该疾病的发病机制似乎与以皮肤、关节和肌腱附着点为靶点的辅助性T细胞17极化免疫反应有关。最后，随着越来越多的患者群体接受先进的基因筛查方法，对该疾病遗传病因的新见解正在不断涌现。
