Sakamoto Kei
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, UK.
Cell Metab. 2008 Jan;7(1):3-4. doi: 10.1016/j.cmet.2007.12.005.
SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.
SIRT1是一种依赖烟酰胺腺嘌呤二核苷酸（NAD(+)）的蛋白质脱乙酰酶，可调节参与关键细胞过程的转录因子，被认为是热量限制有益作用的介质。在最近一期的《自然》杂志上，米尔恩等人（2007年）描述了SIRT1的新型强效激活剂，将其给予胰岛素抵抗动物可改善葡萄糖稳态。
