Herbein Georges, Khan Kashif Aziz
Department of Virology, EA3186, IFR133, Franche-Comté University, Hôpital Saint-Jacques, Besançon Cedex, France.
Trends Immunol. 2008 Feb;29(2):61-7. doi: 10.1016/j.it.2007.10.008.
Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both to apoptosis of uninfected bystander T cells and to sustained viral replication in infected T cells and macrophages. This article proposes a model that highlights the role of HIV proteins in the modulation of TNF receptor signalling and could explain both immune suppression and the formation of viral reservoirs during HIV infection.
最近的研究表明，肿瘤坏死因子（TNF）受体信号传导在HIV感染中起着关键作用。已证实HIV蛋白靶向TNF受体信号传导，这既导致未感染的旁观者T细胞凋亡，也导致感染的T细胞和巨噬细胞中病毒持续复制。本文提出了一个模型，该模型突出了HIV蛋白在调节TNF受体信号传导中的作用，并可以解释HIV感染期间的免疫抑制和病毒储存库的形成。
