Massie Jamie A M, Burney Richard O, Milki Amin A, Westphal Lynn M, Lathi Ruth B
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA.
Fertil Steril. 2008 Dec;90(6):2351-5. doi: 10.1016/j.fertnstert.2007.10.041. Epub 2008 Jan 7.
To determine whether an elevated basal FSH concentration is an independent predictor of fetal aneuploidy, as measured in spontaneous abortions (SAB).
Retrospective study.
Academic reproductive endocrinology and infertility center.
PATIENT(S): All women with karyotypes of chorionic villi isolated from first trimester spontaneous miscarriages at the time of dilation and curettage from 1999 to 2006. The highest basal serum FSH level in the year preceding dilation and curettage was recorded.
INTERVENTIONS(S): Monitoring of early pregnancy.
MAIN OUTCOME MEASURE(S): Fetal karyotype.
RESULTS(S): A total of 177 spontaneous miscarriages with karyotypes (70 euploid and 107 aneuploid) were identified, of which 53% were conceived by IVF. The aneuploid cohort consisted of trisomic (87%), teraploid (9.3%), and monosomic (3.7%) gestations. Using logistic regression analysis, basal FSH was not found to be independently predictive of an aneuploid gestation in our data set.
CONCLUSION(S): Our data do not support the hypothesis that an elevated basal FSH concentration is associated with an increase in fetal aneuploidy. Our findings suggest that the association between diminished ovarian reserve and SAB may result from nonkaryotypic factors.
确定基础促卵泡激素（FSH）浓度升高是否为胎儿非整倍体的独立预测指标，该指标通过自然流产（SAB）来衡量。
回顾性研究。
学术性生殖内分泌与不孕症中心。
1999年至2006年期间，所有在刮宫时从孕早期自然流产中分离出的绒毛膜绒毛核型正常的女性。记录刮宫前一年的最高基础血清FSH水平。
监测早期妊娠。
胎儿核型。
共鉴定出177例具有核型的自然流产（70例整倍体和107例非整倍体），其中53%是通过体外受精受孕的。非整倍体队列包括三体妊娠（87%）、四倍体妊娠（9.3%）和单体妊娠（3.7%）。使用逻辑回归分析，在我们的数据集中未发现基础FSH是胎儿非整倍体妊娠的独立预测指标。
我们的数据不支持基础FSH浓度升高与胎儿非整倍体增加相关的假设。我们的研究结果表明，卵巢储备功能减退与自然流产之间的关联可能是由非核型因素导致的。
