Stanford Fertility and Reproductive Medicine Center, Palo Alto, California 94304,
Fertil Steril. 2011 Mar 1;95(3):970-2. doi: 10.1016/j.fertnstert.2010.07.1088. Epub 2010 Sep 15.
To examine the rate of aneuploidy in missed abortions in patients who conceived after FSH ovarian stimulation compared with women who conceived in a natural cycle.
Retrospective cohort.
Academic reproductive endocrinology and infertility center.
PATIENT(S): Women with karyotyping of products of conception (POC) from a missed abortion from January 1999 through August 2007. The rate of aneuploidy was compared between patients with a history of infertility who conceived naturally and patients with a history of infertility who conceived with FSH treatment.
INTERVENTION(S): Ovarian stimulation with FSH, intrauterine insemination, and in vitro fertilization; genetic testing of POC after dilation and curettage.
MAIN OUTCOME MEASURE(S): Embryonic karyotype.
RESULT(S): A total of 229 pregnancies met inclusion criteria, and of these, 64% had an abnormal karyotype. The rate of aneuploidy was 63% in the study group and 70% in the control group. This difference was not statistically significant.
CONCLUSION(S): The incidence of embryonic aneuploidy was not higher in pregnancies conceived with FSH stimulation compared with spontaneous conceptions in infertility patients. This suggests that exogenous FSH exposure does not increase the risk of aneuploidy.
研究体外受精-胚胎移植（IVF-ET）周期中，因稽留流产行绒毛染色体核型分析患者的胚胎非整倍体发生率，并与自然妊娠患者进行比较。
回顾性队列研究。
生殖内分泌和不孕不育中心。
2007 年 8 月 1 日前，因稽留流产行绒毛染色体核型分析的患者。将有不孕病史且行 IVF-ET 周期妊娠患者设为观察组，有不孕病史且行自然妊娠患者设为对照组，比较两组患者胚胎非整倍体发生率。
采用促性腺激素（FSH）促排卵、宫腔内人工授精（IUI）和体外受精（IVF）等方法治疗。行刮宫术，并对绒毛组织进行遗传学检测。
胚胎染色体核型。
共 229 例患者符合纳入标准，其中 64%患者胚胎染色体核型异常。观察组胚胎非整倍体发生率为 63%，对照组为 70%，两组比较差异无统计学意义。
体外受精-胚胎移植周期中 FSH 暴露并不增加胚胎非整倍体的发生风险。
