格林-巴利综合征中与感染及临床病程相关的运动神经节苷脂的IgG亚类。

Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome.

作者信息

Jacobs Bart C, Koga Michiaki, van Rijs Wouter, Geleijns Karin, van Doorn Pieter A, Willison Hugh J, Yuki Nobuhiro

机构信息

Department of Neurology, Erasmus MC, P.O. BOX 2040, 3000 CA Rotterdam, The Netherlands.

出版信息

J Neuroimmunol. 2008 Feb;194(1-2):181-90. doi: 10.1016/j.jneuroim.2007.11.017. Epub 2008 Feb 21.

DOI:10.1016/j.jneuroim.2007.11.017

PMID:18178257

Abstract

In 176 patients with Guillain-Barré syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C. jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome.

摘要

在176例吉兰-巴雷综合征患者中，血清IgG抗体对运动神经节苷脂的亚类和交叉反应性与先前感染及临床表型相关。确定了两组患者。仅存在IgG1抗体与腹泻、空肠弯曲菌血清学阳性、对空肠弯曲菌脂寡糖的交叉反应性抗体及不良预后相关。相比之下，同时存在IgG1和IgG3抗体与上呼吸道感染、对流感嗜血杆菌脂寡糖的交叉反应性抗体及较好预后相关。这些发现支持了一种模型，即空肠弯曲菌和流感嗜血杆菌感染诱导出具有不同临床结果的两种不同交叉反应性抗体模式。