Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
J Clin Neurosci. 2021 Jan;83:119-122. doi: 10.1016/j.jocn.2020.11.013. Epub 2020 Nov 14.
The global SARS-CoV-2 pandemic posed an unprecedented challenge to almost all fields of medicine and Neurology is not an exception. Collecting information about its complications and related conditions will help clinicians to become more confident in managing this disease. Guillain-Barre Syndrome (GBS) is mostly described as a post-infectious phenomenon and its occurrence during acute phase of illness is of interest. GBS has recently been reported during the active phase of COVID-19 for the first time. Severity and fast progression of GBS associated with COVID-19 have also been shown in recent studies. Here we report three cases of GBS during the active phase of COVID-19 with severe symptoms and fast progression to quadriplegia and facial diplegia over 2 days, which led to death in one case due to severe autonomic dysfunction. We suggest SARS-CoV-2 might be associated with rather a severe, rapidly progressive and life-threatening phenotype of GBS.
全球 SARS-CoV-2 大流行对几乎所有医学领域都构成了前所未有的挑战，神经病学也不例外。收集有关其并发症和相关病症的信息将有助于临床医生更有信心地治疗这种疾病。格林-巴利综合征（GBS）主要被描述为一种感染后现象，其在疾病急性期的发生引起了关注。最近首次报道了 COVID-19 活跃期发生 GBS 的情况。最近的研究还表明，与 COVID-19 相关的 GBS 严重程度和快速进展。在此，我们报告了 3 例 COVID-19 活跃期 GBS 病例，症状严重，在 2 天内迅速进展为四肢瘫痪和面瘫，其中 1 例因严重自主神经功能障碍而死亡。我们认为 SARS-CoV-2 可能与 GBS 更为严重、快速进展和危及生命的表型有关。
