Aslam Ahmad K, Rodriguez Carlos, Aslam Ahmed F, Vasavada Balendu C, Khan Ijaz A
Int J Cardiol. 2009 Mar 20;133(1):138-9. doi: 10.1016/j.ijcard.2007.08.135. Epub 2008 Feb 21.
Gross and microscopic findings consistent with acute and healed myocardial injury without coronary artery disease have been described in autopsy studies of patients with sickle cell crisis. The present study was designed to determine whether serum levels of cardiac troponin I are elevated in sickle cell crisis. Cardiac troponin I levels were measured in 32 patients age>18 years with the admission diagnosis of sickle cell crisis. All patients had cardiac troponin I level drawn >24 h after the onset of symptoms. The clinical profile and electrocardiograms were analyzed. Out of 32 patients, 2 patients had serum cardiac troponin I elevated, both had presented with acute chest syndrome. Serum cardiac troponin I may be elevated during sickle cell crisis, possibly by myocardial ischemia resulting from microvascular coronary obstruction during sickle cell crisis.
在镰状细胞危象患者的尸检研究中，已描述了与无冠状动脉疾病的急性和愈合心肌损伤相符的大体和微观表现。本研究旨在确定镰状细胞危象患者的血清心肌肌钙蛋白I水平是否升高。对32名年龄>18岁、入院诊断为镰状细胞危象的患者测量了心肌肌钙蛋白I水平。所有患者在症状发作>24小时后检测心肌肌钙蛋白I水平。分析了临床特征和心电图。32名患者中，2名患者血清心肌肌钙蛋白I升高，二者均出现急性胸部综合征。镰状细胞危象期间血清心肌肌钙蛋白I可能升高，可能是由于镰状细胞危象期间微血管冠状动脉阻塞导致心肌缺血。
