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通过在酿酒酵母中进行跨域互补鉴定N-连接糖基化系统的古菌alg7基因同源物（编码N-乙酰葡糖胺-1-磷酸转移酶）。

Identification of the archaeal alg7 gene homolog (encoding N-acetylglucosamine-1-phosphate transferase) of the N-linked glycosylation system by cross-domain complementation in Saccharomyces cerevisiae.

作者信息

Shams-Eldin Hosam, Chaban Bonnie, Niehus Sebastian, Schwarz Ralph T, Jarrell Ken F

机构信息

Institute for Virology, AG Parasitologie BMFZ, Philipps-University Marburg, Hans-Meerwein-Str. 2, 35043 Marburg, Germany.

出版信息

J Bacteriol. 2008 Mar;190(6):2217-20. doi: 10.1128/JB.01778-07. Epub 2008 Jan 4.

DOI:10.1128/JB.01778-07
PMID:18178736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258894/
Abstract

The Mv1751 gene product is thought to catalyze the first step in the N-glycosylation pathway in Methanococcus voltae. Here, we show that a conditional lethal mutation in the alg7 gene (N-acetylglucosamine-1-phosphate transferase) in Saccharomyces cerevisiae was successfully complemented with Mv1751, highlighting a rare case of cross-domain complementation.

摘要

Mv1751基因产物被认为催化沃氏甲烷球菌中N-糖基化途径的第一步。在此，我们表明酿酒酵母中alg7基因（N-乙酰葡糖胺-1-磷酸转移酶）的条件致死突变成功地被Mv1751互补，突出了跨域互补的罕见情况。

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本文引用的文献

1
Identification of genes involved in the biosynthesis and attachment of Methanococcus voltae N-linked glycans: insight into N-linked glycosylation pathways in Archaea.参与沃氏甲烷球菌N-连接聚糖生物合成和连接的基因鉴定：对古菌中N-连接糖基化途径的深入了解。
Mol Microbiol. 2006 Jul;61(1):259-68. doi: 10.1111/j.1365-2958.2006.05226.x.
2
Protein N-glycosylation in Archaea: defining Haloferax volcanii genes involved in S-layer glycoprotein glycosylation.古菌中的蛋白质N-糖基化：确定参与S层糖蛋白糖基化的嗜盐栖热袍菌基因。
Mol Microbiol. 2006 Jul;61(2):511-25. doi: 10.1111/j.1365-2958.2006.05252.x. Epub 2006 Jun 6.
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Posttranslational protein modification in Archaea.古菌中的蛋白质翻译后修饰
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Modeling bacterial UDP-HexNAc: polyprenol-P HexNAc-1-P transferases.细菌UDP-己糖胺：聚戊烯醇-P己糖胺-1-P转移酶的建模
Glycobiology. 2005 Sep;15(9):29R-42R. doi: 10.1093/glycob/cwi065. Epub 2005 Apr 20.
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Identification and characterization of the unique N-linked glycan common to the flagellins and S-layer glycoprotein of Methanococcus voltae.沃氏甲烷球菌鞭毛蛋白和S层糖蛋白共有的独特N-连接聚糖的鉴定与表征
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Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase family.区分聚戊烯醇磷酸酯：N-乙酰己糖胺-1-磷酸转移酶家族亚组的保守细胞质基序。
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Glycoconj J. 1999 Nov;16(11):673-9. doi: 10.1023/a:1007132907235.