两个是否比一个更好？血管紧张素转换酶抑制剂加血管紧张素受体阻滞剂用于降低肾病患者的血压和蛋白尿
Are two better than one? Angiotensin-converting enzyme inhibitors plus angiotensin receptor blockers for reducing blood pressure and proteinuria in kidney disease.
作者信息
Linas Stuart L
机构信息
Department of Internal Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA.
出版信息
Clin J Am Soc Nephrol. 2008 Jan;3 Suppl 1(Suppl 1):S17-23. doi: 10.2215/CJN.03270807.
Abstract
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers each reduce proteinuria and blood pressure. Several studies have compared the antiproteinuric and antihypertensive effects of combination therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with those of therapy with either drug class alone. This article reviews those trials as well as evidence suggesting a mechanism for the benefits observed with combination therapy.
摘要
血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂均可降低蛋白尿和血压。多项研究比较了血管紧张素转换酶抑制剂与血管紧张素受体阻滞剂联合治疗的抗蛋白尿和降压效果与单独使用这两类药物治疗的效果。本文回顾了这些试验以及提示联合治疗获益机制的证据。
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