De Mast Q, Sweep F C G J, McCall M, Geurts-Moespot A, Hermsen C, Calandra T, Netea M G, Sauerwein R W, van der Ven A J M
Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Parasite Immunol. 2008 Mar;30(3):133-8. doi: 10.1111/j.1365-3024.2007.01008.x. Epub 2007 Dec 19.
Macrophage migration inhibitory factor (MIF) has recently been implicated in the pathogenesis of malarial anaemia. However, field studies have reported contradictory results on circulating MIF concentrations in patients with clinically overt Plasmodium falciparum malaria. We determined plasma MIF levels over time in 10 healthy volunteers during experimental P. falciparum infection. Under fully controlled conditions, MIF levels decreased significantly during early blood-stage infection and reached a nadir at day 8 post-infection. A decrease in the number of circulating lymphocytes, which are an important source of MIF production, paralleled the decrease in MIF levels. Monocyte/macrophage counts remained unchanged. At MIF nadir, the anti-inflammatory cytokine interleukin (IL)-10, which is an inhibitor of T-cell MIF production, was detectable in only 2 of 10 volunteers. Plasma concentrations of the pro-inflammatory cytokines IL-8 and IL-1beta were only marginally elevated. We conclude that circulating MIF levels decrease early in blood-stage malaria as a result of the decline in circulating lymphocytes.
巨噬细胞移动抑制因子（MIF）最近被认为与疟疾贫血的发病机制有关。然而，实地研究报告了关于临床显性恶性疟原虫疟疾患者循环MIF浓度的矛盾结果。我们在10名健康志愿者实验性感染恶性疟原虫期间，随时间测定了血浆MIF水平。在完全受控的条件下，MIF水平在早期血液阶段感染期间显著下降，并在感染后第8天降至最低点。作为MIF产生的重要来源的循环淋巴细胞数量的减少与MIF水平的下降平行。单核细胞/巨噬细胞计数保持不变。在MIF最低点时，作为T细胞MIF产生抑制剂的抗炎细胞因子白细胞介素（IL）-10仅在10名志愿者中的2名中可检测到。促炎细胞因子IL-8和IL-1β的血浆浓度仅略有升高。我们得出结论，血液阶段疟疾早期循环MIF水平下降是循环淋巴细胞减少的结果。
