Xiao Jing, Zhang Fan, Wiltshire Steven, Hung Joseph, Jennens Michelle, Beilby John P, Thompson Peter L, McQuillan Brendan M, McCaskie Pamela A, Carter Kim W, Palmer Lyle J, Powell Brenda L
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Australia.
Atherosclerosis. 2008 Aug;199(2):333-9. doi: 10.1016/j.atherosclerosis.2007.11.017. Epub 2008 Jan 7.
Serum high density lipoprotein (HDL) levels are inversely related to the development of coronary artery disease (CAD). Apolipoproteins AI and AII are the major protein constituents of HDL particles. APOAI and APOAII genetic polymorphisms have been proposed to affect transcriptional efficiency of their respective genes, thereby altering serum lipid levels and influencing atherosclerotic disease risk. 556 subjects with angiographically proven CAD (>50% stenosis) and 1109 randomly selected individuals from metropolitan Perth, Western Australia, were included in an association study. APOAI -75G/A (rs670) and APOAII -256T/C (rs5082) polymorphisms were both found to be not associated with plasma HDL levels. In a case-control analysis of 484 male CAD patients and 498 male controls, individuals carrying the 'CC' genotype for the APOAII rs5082 polymorphism had significantly lower risk of CAD than the 'T' allele carriers (OR=0.57, 95% CI 0.39-0.84, p=0.004). The minor 'A' allele of the APOAI rs670 polymorphism was found to be not associated with CAD, contrary to previous reports. We conclude that the APOAII rs5082 polymorphism appears to be cardioprotective in this representative Caucasian Australian population.
血清高密度脂蛋白（HDL）水平与冠状动脉疾病（CAD）的发生呈负相关。载脂蛋白AI和AII是HDL颗粒的主要蛋白质成分。有人提出APOAI和APOAII基因多态性会影响各自基因的转录效率，从而改变血脂水平并影响动脉粥样硬化疾病风险。一项关联研究纳入了556名经血管造影证实患有CAD（狭窄>50%）的受试者以及1109名从澳大利亚西部珀斯市随机选取的个体。研究发现，APOAI -75G/A（rs670）和APOAII -256T/C（rs5082）多态性均与血浆HDL水平无关。在对484名男性CAD患者和498名男性对照进行的病例对照分析中，携带APOAII rs5082多态性“CC”基因型的个体患CAD的风险显著低于“T”等位基因携带者（OR = 0.57，95% CI 0.39 - 0.84，p = 0.004）。与之前的报道相反，APOAI rs670多态性的次要“A”等位基因与CAD无关。我们得出结论，在这个具有代表性的澳大利亚白种人群体中，APOAII rs5082多态性似乎具有心脏保护作用。
