Yao Qing-He, Zhang Hua, Wang Hai-Wei, Jing Xiao-Rong, Guo Heng, Gao Guo-Dong
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xin-shi Road, Shaanxi Province, Xi'an, China.
Neurosci Lett. 2008 Jan 17;430(3):187-90. doi: 10.1016/j.neulet.2007.10.024. Epub 2007 Oct 30.
The clinic treatment of epilepsy with epileptic foci overlapped with eloquent cortex is not satisfactory. In this study we investigated the direct effects of low- and high-frequency electric cortical stimulation (ECS) on ferric chloride-induced seizures in the experimental rats. Results showed that spontaneous seizures were observed in all rats during the EEG recording after the intracortical injection of ferric chloride solution into left sensorimotor cortex. One-hertz or 100-Hz ECS with 0.3 ms duration and 0.1 mA amplitude square pulses in 1h on the cortical lesioned area significantly decreased the number of seizures compared with that of the non-stimulation control group. The mean duration time of seizures in 1-Hz or 100-Hz groups was apparently shorter than that in the control group. In brief, this study showed that both low- and high-frequency ECS suppressed the seizures induced by ferric chloride in rats, indicating their potential treatment effects on epilepsy in clinic.
癫痫病灶与明确的皮质重叠的癫痫患者的临床治疗效果并不理想。在本研究中，我们研究了低频和高频电皮质刺激（ECS）对实验大鼠氯化铁诱导的癫痫发作的直接影响。结果显示，在将氯化铁溶液皮层内注射到左侧感觉运动皮层后，所有大鼠在脑电图记录期间均观察到自发性癫痫发作。与非刺激对照组相比，在皮层损伤区域以1小时内0.3毫秒持续时间和0.1毫安振幅的方波脉冲进行1赫兹或100赫兹的ECS显著减少了癫痫发作的次数。1赫兹或100赫兹组癫痫发作的平均持续时间明显短于对照组。简而言之，本研究表明低频和高频ECS均能抑制大鼠氯化铁诱导的癫痫发作，表明它们在临床上对癫痫具有潜在的治疗作用。
