Guo Heng, Zhang Hua, Kuang Yongqin, Wang Chao, Jing Xiaorong, Gu Jianwen, Gao Guodong
Department of Neurosurgery, General Hospital of People's Liberation Army Chengdu Military Region, 270 Rongdu Road, Chengdu, Sichuan, 610083, China.
J Mol Neurosci. 2014 Aug;53(4):546-52. doi: 10.1007/s12031-013-0220-4. Epub 2014 Jan 8.
Deep brain stimulation is an alternate treatment strategy for intractable epilepsy. The effects of low- and high-frequency electrical stimulation to the substantia nigra pars reticulata (SNr) of different sides on chemically induced neocortical seizure were investigated in the present study. After neocortical seizure was induced by ferric chloride injection into the left sensorimotor cortex, SNr was stimulated ipsilaterally, contralaterally, or bilaterally at frequencies of 130 or 20 Hz in rats. Unilateral and bilateral stimulation at 130 Hz reduced significantly the number of seizures but not their duration. Ipsilateral, contralateral as well as bilateral stimulations at 130 Hz were all equally effective, producing reductions in seizures of 63.62, 77.84, and 68.74% compared with the control group, respectively. Electrical stimulation at 20 Hz did not reduce the number or duration of seizures regardless of the side stimulated. Both unilateral and bilateral stimulations of SNr at 130 Hz can suppress ictogenesis in the cortex, but electrical stimulation at 130 or 20 Hz does not reduce the severity of individual seizures. The frequency of stimulation is paramount in suppressing neocortical seizures in which DBS at least targets SNr.
脑深部电刺激是治疗顽固性癫痫的一种替代治疗策略。本研究探讨了不同侧黑质网状部（SNr）低频和高频电刺激对化学诱导的新皮质癫痫的影响。通过向大鼠左侧感觉运动皮层注射氯化铁诱导新皮质癫痫后，分别以130Hz或20Hz的频率对大鼠的SNr进行同侧、对侧或双侧刺激。130Hz的单侧和双侧刺激显著减少了癫痫发作次数，但未缩短发作持续时间。130Hz的同侧、对侧以及双侧刺激效果均相同，与对照组相比，癫痫发作次数分别减少了63.62%、77.84%和68.74%。无论刺激哪一侧，20Hz的电刺激均未减少癫痫发作次数或缩短发作持续时间。130Hz的SNr单侧和双侧刺激均可抑制皮质癫痫发作的产生，但130Hz或20Hz的电刺激均未降低单次癫痫发作的严重程度。在抑制新皮质癫痫发作方面，刺激频率至关重要，其中脑深部电刺激至少以SNr为靶点。
