Bucci Frank A, Amico Loretta M, Evans Ruth E
Bucci Laser Vision Institute, Wilkes Barre, PA 18702, USA.
Eye Contact Lens. 2008 Jan;34(1):39-42. doi: 10.1097/ICL.0b013e3180645d01.
To evaluate the ocular surface and aqueous antimicrobial effects of gatifloxacin and moxifloxacin administered in two dosing regimens to patients undergoing phacoemulsification.
Patients were divided between two treatment groups and randomized to receive gatifloxacin 0.3% or moxifloxacin 0.5% within each group. Group 1 patients received antibiotics four times per day for 2 days before surgery with one additional drop the morning of surgery (n=50, each drug). Group 2 patients were treated as in group 1, plus four drops (one drop every 10 minutes) during the hour before surgery (n=60, each drug). Conjunctival and eyelid swabs were taken before surgery, and aqueous humor cultures were obtained immediately after surgery. Pathogens were identified and colony-forming units (CFUs) were counted.
No differences were observed between the antibiotics in mean CFUs in conjunctival cultures from group 1 (gatifloxacin, 59.9+/-165.6 CFUs; moxifloxacin, 57.0+/-214.7 CFUs; P=0.939) or group 2 (gatifloxacin, 76.7+/-327.7 CFUs; moxifloxacin, 92.0+/-486.1 CFUs; P=0.830). No differences were observed between antibiotics in mean CFUs in eyelid cultures from group 1 (gatifloxacin, 198.1+/-330.1 CFUs; moxifloxacin, 168.3+/-379.0; P=0.840) or group 2 (gatifloxacin, 556.8+/-1,029.3 CFUs; moxifloxacin, 596.5+/-1,013.5 CFUs; P=0.832). The overall rate of positive aqueous cultures in the 220 patients from groups 1 and 2 combined was less than 1% (i.e., no difference between antibiotics in either group).
Preoperative topical ophthalmic gatifloxacin and moxifloxacin produced similar preoperative eyelid and conjunctival bacterial counts and identically low postsurgical aqueous contamination rates.
评估在两种给药方案下，加替沙星和莫西沙星对接受白内障超声乳化手术患者的眼表及房水抗菌效果。
患者分为两个治疗组，每组内随机接受0.3%加替沙星或0.5%莫西沙星治疗。第1组患者在手术前2天每天滴药4次，手术当天早晨额外滴1次（每种药物各50例）。第2组患者治疗方式同第1组，但在手术前1小时内加滴4次（每10分钟1次）（每种药物各60例）。手术前采集结膜和眼睑拭子，手术后立即获取房水培养物。鉴定病原体并计数菌落形成单位（CFU）。
第1组（加替沙星，59.9±165.6 CFU；莫西沙星，57.0±214.7 CFU；P = 0.939）或第2组（加替沙星，76.7±327.7 CFU；莫西沙星，92.0±486.1 CFU；P = 0.830）结膜培养物中，两种抗生素的平均CFU无差异。第1组（加替沙星，198.1±330.1 CFU；莫西沙星，168.3±379.0；P = 0.840）或第2组（加替沙星，556.8±1,029.3 CFU；莫西沙星，596.5±1,013.5 CFU；P = 0.832）眼睑培养物中，两种抗生素的平均CFU也无差异。第1组和第2组共220例患者房水培养阳性的总体发生率低于1%（即两组中两种抗生素之间无差异）。
术前局部应用眼科加替沙星和莫西沙星产生相似的术前眼睑和结膜细菌计数，术后房水污染率同样低。
