Goodwin Victoria A, Richards Suzanne H, Taylor Rod S, Taylor Adrian H, Campbell John L
Primary Care Research Group, Peninsula Medical School, Exeter, United Kingdom.
Mov Disord. 2008 Apr 15;23(5):631-40. doi: 10.1002/mds.21922.
Parkinson's disease (PD) is a neurodegenerative disorder affecting the physical, psychological, social, and functional status of individuals. Exercise programs may be an effective strategy to delay or reverse functional decline for people with PD and a large body of empirical evidence has emerged in recent years. The objective is to systematically review randomized controlled trials (RCTs) reporting on the effectiveness of exercise interventions on outcomes (physical, psychological or social functioning, or quality of life) for people with PD. RCTs meeting the inclusion criteria were identified by systematic searching of electronic databases. Key data were extracted by two independent researchers. A mixed methods approach was undertaken using narrative, vote counting, and random effects meta-analysis methods. Fourteen RCTs were included and the methodological quality of most studies was moderate. Evidence supported exercise as being beneficial with regards to physical functioning, health-related quality of life, strength, balance and gait speed for people with PD. There was insufficient evidence support or refute the value of exercise in reducing falls or depression. This review found evidence of the potential benefits of exercise for people with PD, although further good quality research is needed. Questions remain around the optimal content of exercise interventions (dosing, component exercises) at different stages of the disease.
帕金森病（PD）是一种神经退行性疾病，会影响个体的身体、心理、社会和功能状态。运动计划可能是延缓或逆转帕金森病患者功能衰退的有效策略，近年来已出现大量实证证据。目的是系统评价随机对照试验（RCT），这些试验报告了运动干预对帕金森病患者结局（身体、心理或社会功能，或生活质量）的有效性。通过系统检索电子数据库来识别符合纳入标准的RCT。关键数据由两名独立研究人员提取。采用叙述性、计数投票和随机效应荟萃分析方法进行混合方法研究。纳入了14项RCT，大多数研究的方法学质量中等。有证据表明运动对帕金森病患者的身体功能、健康相关生活质量、力量、平衡和步速有益。没有足够的证据支持或反驳运动在减少跌倒或抑郁方面的价值。本综述发现了运动对帕金森病患者潜在益处的证据，尽管还需要进一步的高质量研究。围绕疾病不同阶段运动干预的最佳内容（剂量、组成运动）仍存在问题。
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