Do Hien-Quang, Daugulis Olafs
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
J Am Chem Soc. 2008 Jan 30;130(4):1128-9. doi: 10.1021/ja077862l. Epub 2008 Jan 9.
An efficient, copper-catalyzed method for the arylation, alkenylation, and benzylation of polyfluoroarenes has been developed. Arenes containing two or more fluorine substituents on the aromatic ring can be efficiently functionalized. The best results are obtained by using a combination of copper iodide catalyst, phenanthroline ligand, aryl bromide or aryl iodide coupling partner and DMF or DMF/xylene mixed solvent.
已开发出一种高效的铜催化方法,用于多氟芳烃的芳基化、烯基化和苄基化反应。在芳环上含有两个或更多氟取代基的芳烃能够被有效地官能化。通过使用碘化铜催化剂、菲咯啉配体、芳基溴化物或芳基碘化物偶联试剂以及N,N-二甲基甲酰胺(DMF)或DMF/二甲苯混合溶剂的组合,可获得最佳结果。