Notch1、Jagged1和VEGF在人非小细胞肺癌中的表达及意义

[Expression and significance of Notch1, Jagged1 and VEGF in human non-small cell lung cancer].

作者信息

Jiang Xin, Zhou Jian-hua, Deng Zheng-hao, Qu Xiao-hui, Jiang Hai-ying, Liu Ying

机构信息

Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Dec;32(6):1031-6.

PMID:18182722

Abstract

OBJECTIVE

To determine the expressions of Notch1, Jagged1 and vascular endothelial growth factor (VEGF) in human non-small cell lung cancer (NSCLC) and to explore its clinical pathological significance.

METHODS

Immunohistochemical SP method was used to detect the expressions of Notch1, Jagged1 and VEGF in 65 patients with NSCLC and 15 normal epithelial tissues of the lung, and the relationship between them and clinic-pathological parameters were analyzed.

RESULTS

The positive rates of Notch1, Jagged1 and VEGF in NSCLC were 81.5%, 83.1% and 93.8%, respectively, higher than those in normal epithelial tissues of the lung (P<0.05). The positive expression levels of Notch1 and VEGF were closely associated with the tumor stage and the lymph node metastasis (P<0.05). The positive expression levels of Jagged1 was positively correlated with the pathological type and lymph node metastasis. There was a positive correlation between Notch1, Jagged1 and VEGF.

CONCLUSION

Notch1, Jagged1 and VEGF protein may play an important role in the pathway of carcinogenesis and progression of NSCLC. The up-regulation of Notch1, Jagged1 and VEGF protein expression probably predict NSCLC carrying relatively strong permeation and metastasis.

摘要

目的

检测Notch1、Jagged1和血管内皮生长因子（VEGF）在人非小细胞肺癌（NSCLC）中的表达，探讨其临床病理意义。

方法

采用免疫组织化学SP法检测65例NSCLC患者及15例正常肺上皮组织中Notch1、Jagged1和VEGF的表达，并分析它们与临床病理参数的关系。

结果

NSCLC中Notch1、Jagged1和VEGF的阳性率分别为81.5%、83.1%和93.8%，高于正常肺上皮组织（P<0.05）。Notch1和VEGF的阳性表达水平与肿瘤分期和淋巴结转移密切相关（P<0.05）。Jagged1的阳性表达水平与病理类型和淋巴结转移呈正相关。Notch1、Jagged1和VEGF之间呈正相关。