Guo Lixia, Zhang Ting, Xiong Ying, Yang Yanan
Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA ; School of Arts and Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dis Markers. 2015;2015:520590. doi: 10.1155/2015/520590. Epub 2015 Sep 27.
Lung cancer is one of the most common types of human malignancies and the leading cause of cancer-related death. Patients with surgically resectable early stage lung cancer are more likely curable, but currently only a small population of patients can be diagnosed at such a stage, partly due to our incomplete understanding of the biology of lung cancer and the lack of diagnostic and prognostic biomarkers. Recent studies have shown that NOTCH1 is a critical regulator of human carcinogenesis and has been implicated in multiple steps of cancer development and progression. Herein, we review recent findings about the role of NOTCH1 in lung cancer and discuss its potential usefulness as both a therapeutic target and a biomarker for lung cancer.
肺癌是人类最常见的恶性肿瘤类型之一，也是癌症相关死亡的主要原因。可手术切除的早期肺癌患者更有可能治愈，但目前只有一小部分患者能在这个阶段被诊断出来，部分原因是我们对肺癌生物学的理解不完整，以及缺乏诊断和预后生物标志物。最近的研究表明，NOTCH1是人类致癌作用的关键调节因子，并参与了癌症发展和进展的多个步骤。在此，我们综述了关于NOTCH1在肺癌中作用的最新研究结果，并讨论了其作为肺癌治疗靶点和生物标志物的潜在用途。
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