[Analysis of the causes of incomplete structural and functional restoration of the skeletal muscles after severe traumatic injury to the limb (ultrastructural study)].

The work is concerned with light-optic and ultrastructural analysis of the causes of incomplete structural and functional restoration of skeletal muscles after extensive trauma and replantation of the limb. It was found that posttraumatic myogenesis was limited due to change of some of the satellite cells from the myogenic type of development to differentiation with the formation of fibroblast-like cells. In distinction from the embryonal cells, the myoblasts form the surrounding basal membranes earlier which prevents their fusion and the formation of the myosymplast. The features of the macrophageal reaction, its permanency lead to accumulation of collagen in the interstitium. Progressing secondary neurogenic atrophy develops at the tissue level. The developing posttraumatic microangiopathies are the cause of secondary destructive changes in the muscles. The disorders of tissue nutrition and the progressing atrophic and destructive-degenerative processes gear the autoimmune mechanisms in the late periods which is conducive to stable chronicity of the pathological process in the muscle.