Brouet J C, Levy Y
Laboratoire d'Immunochimie et d'Immunopathologie, U108 INSERM, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1991;33(6):433-6.
Interleukin 6 has pleiotropic effects on cells from various lineages. Several data indicate that it may play a critical role in the development of multiple myeloma by an autocrine or parcrine stimulation pathway. For instance, we showed that oligodeoxynucleotides antisens of IL6 mRNA were capable to decrease the proliferation of two different myeloma cell lines. In Waldenström's macroglobulinemia, at the initial stage of the disease, there is an autocrine differentiation pathway which is dependent of the secretion of IL6 by tumor cells. IL6 may also be implicated in the pathogenesis of some other lymphoid malignancies such as follicular lymphomas or large cell lymphomas. Its role in the systemic symptoms of Castleman disease has been clearly established.
白细胞介素6对来自不同谱系的细胞具有多效性作用。多项数据表明，它可能通过自分泌或旁分泌刺激途径在多发性骨髓瘤的发展中起关键作用。例如，我们发现IL6 mRNA的反义寡脱氧核苷酸能够降低两种不同骨髓瘤细胞系的增殖。在华氏巨球蛋白血症中，在疾病的初始阶段，存在一种依赖肿瘤细胞分泌IL6的自分泌分化途径。IL6也可能与其他一些淋巴恶性肿瘤的发病机制有关，如滤泡性淋巴瘤或大细胞淋巴瘤。它在Castleman病全身症状中的作用已得到明确证实。
