Yoshizaki K, Kuritani T, Kishimoto T
Department of Medicine III, Osaka University Medical School, Japan.
Semin Immunol. 1992 Jun;4(3):155-66.
Interleukin-6, a pleiotropic cytokine, appears to play a key role as a physiologically functioning molecule in host defense mechanisms. Previous reports have suggested that dysregulated interleukin-6 production may be involved in lymph node hyperplasia, plasmacytosis, immunoglobulin hyperproduction, thrombocytosis, mesangial cell proliferation and acute phase response, all of which are frequently observed in autoimmune disorders. In this report, we discuss the possible involvement of interleukin-6 in the pathogenesis of a variety of autoimmune diseases and the regulatory mechanism of expression of the interleukin-6 gene.
白细胞介素-6是一种多效性细胞因子，作为一种在宿主防御机制中发挥生理功能的分子，似乎起着关键作用。先前的报道表明，白细胞介素-6产生失调可能与淋巴结增生、浆细胞增多、免疫球蛋白过度产生、血小板增多、系膜细胞增殖和急性期反应有关，所有这些在自身免疫性疾病中都经常观察到。在本报告中，我们讨论了白细胞介素-6可能参与多种自身免疫性疾病的发病机制以及白细胞介素-6基因表达的调控机制。
