Khankan Azzam A, Murakami Takamichi, Onishi Hiromitsu, Matsushita Masaki, Iannaccone Riccardo, Aoki Yoshiko, Tono Takeshi, Kim Tonsok, Hori Masatoshi, Osuga Keigo, Passariello Roberto, Nakamura Hironobu
Department of Radiology, Damascus University Hospital, Damascus, Syria.
J Magn Reson Imaging. 2008 Mar;27(3):546-51. doi: 10.1002/jmri.21050.
To determine the usefulness of nonenhanced T1-weighted spoiled gradient-recalled acquisition in the steady-state (SPGR) MRI in the early assessment of the efficacy of radio frequency (RF) therapy for hepatocellular carcinoma (HCC).
A total of 23 patients with 28 HCC nodules treated with percutaneous RF ablation underwent nonenhanced MRI within two days after the RF procedure and contrast-enhanced computed tomography (CT) one week after. MR assessment of ablation efficacy according to the concentric zonal pattern on T1-weighted SPGR imaging was compared with the one-week CT and presence of local recurrence by means of follow-up study for 12 months or more.
In 18 of 28 ablated nodules, SPGR images revealed a central hyperintense zone covering the entire tumor, CT showed a nonenhanced area covering the entire tumor, and no local recurrence was demonstrated in the follow-up studies. In nine of 28 nodules, the central hyperintense zone did not cover the entire tumor; and local recurrence was demonstrated in three nodules. In the remaining one nodule, no signal change was seen in the treated area on SPGR images and CT showed the presence of residual viable tumor.
Nonenhanced T1-weighted MRI was considered useful for early assessment of the efficacy of RF therapy for HCC.
确定在肝细胞癌（HCC）射频（RF）治疗疗效的早期评估中，非增强T1加权稳态扰相梯度回波（SPGR）磁共振成像（MRI）的实用性。
共有23例患有28个HCC结节的患者接受了经皮射频消融治疗，在射频治疗后两天内进行了非增强MRI检查，并在一周后进行了增强计算机断层扫描（CT）。根据T1加权SPGR成像上的同心带状模式对消融疗效进行的MR评估与一周后的CT检查以及通过12个月或更长时间的随访研究观察到的局部复发情况进行了比较。
在28个消融结节中的18个中，SPGR图像显示中央高信号区覆盖整个肿瘤，CT显示整个肿瘤为无强化区，并且在随访研究中未发现局部复发。在28个结节中的9个中，中央高信号区未覆盖整个肿瘤；并且在3个结节中观察到局部复发。在其余1个结节中，SPGR图像上治疗区域未见信号变化，而CT显示存在残留的存活肿瘤。
非增强T1加权MRI被认为对HCC射频治疗疗效的早期评估有用。
