[多种肿瘤标志物检测对卵巢成熟及未成熟畸胎瘤的诊断价值]

[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary].

作者信息

Chen Chen, Li Jun-Dong, Huang He, Feng Yan-Ling, Wang Luan-Hong, Chen Liang

机构信息

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China.

出版信息

Ai Zheng. 2008 Jan;27(1):92-5.

PMID:18184473

Abstract

BACKGROUND & OBJECTIVE: It is difficult to differentially diagnose mature cystic teratoma (MCT) and immature teratoma (IT) of the ovary before operation. This study was to evaluate the value of multiple tumor marker detection in differential diagnosis of ovarian MCT and IT.

METHODS

Clinical data of 272 patients with ovarian teratoma, diagnosed pathologically and treated at Cancer Center of Sun Yat-Sen University from Jan. 1995 to Dec. 2005, were reviewed. Of the 272 patients, 254 had MCT and 18 had IT. The serum levels of carbohydrate antigen 125 (CA125), CA153, CA199, neuron-specific enolase (NSE), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) in MCT and IT were compared.

RESULTS

Of the 254 patients with MCT, the median age was 30, the mean serum levels of CA125, CA153, CA199, NSE, AFP and CEA were 25.5 x 103 u/L, 11.8 x 103 u/L, 106.6 x 103 u/L, 12.6 microg/L, 2.7 microg/L and 2.5 microg/L. Of the 18 patients with IT, the median age was 23, the mean serum levels of these tumor markers were 140.3 x 103 u/L, 16.8 x 103 u/L, 112.0 x 103 u/L, 18.0 microg/L, 369.5 microg/L and 3.2 microg/L. Both the serum levels and positive rates of CA125, CA153 and AFP were significantly higher in IT than in MCT (P<0.05). When detected alone to differentially diagnose MCT and IT, the specificity of CA125, CA153, AFP were high, and the sensitivity of CA125 was the best (50.0%). The sensitivity was elevated to 71.4% by combined detection of CA125, CA153 and AFP.

CONCLUSION

Combined detection of tumor markers, especially CA125, CA153 and AFP, may be helpful for differential diagnosis of ovarian MCT and IT.

摘要

背景与目的

卵巢成熟性囊性畸胎瘤（MCT）与未成熟畸胎瘤（IT）术前难以鉴别诊断。本研究旨在评估多种肿瘤标志物检测在卵巢MCT与IT鉴别诊断中的价值。

方法

回顾性分析1995年1月至2005年12月在中山大学肿瘤防治中心经病理确诊并治疗的272例卵巢畸胎瘤患者的临床资料。272例患者中，MCT 254例，IT 18例。比较MCT与IT患者血清中糖类抗原125（CA125）、CA153、CA199、神经元特异性烯醇化酶（NSE）、甲胎蛋白（AFP）、癌胚抗原（CEA）水平。

结果

254例MCT患者，中位年龄30岁，血清CA125、CA153、CA199、NSE、AFP、CEA平均水平分别为25.5×10³U/L、11.8×10³U/L、106.6×10³U/L、12.6μg/L、2.7μg/L、2.5μg/L。18例IT患者，中位年龄23岁，这些肿瘤标志物的血清平均水平分别为140.3×10³U/L、16.8×10³U/L、112.0×10³U/L、18.0μg/L、369.5μg/L、3.2μg/L。IT患者血清CA125、CA153及AFP水平及阳性率均显著高于MCT患者（P<0.05）。单独检测用于MCT与IT鉴别诊断时，CA125、CA153、AFP特异性较高，其中CA125敏感性最佳（50.0%）。CA125、CA153及AFP联合检测时，敏感性提高至71.4%。