Devoize Laurent, Collangettes Denise, Le Bouëdec Guillaume, Mishellany Florence, Orliaguet Thierry, Dallel Radhouane, Baudet-Pommel Martine
Inserm, Clermont-Ferrand, France.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Mar;105(3):e76-9. doi: 10.1016/j.tripleo.2007.10.001.
Preoperative diagnosis of malignant tumors arising from mature cystic teratoma (MCT) of the ovary is not easy; malignant tumors are mostly diagnosed only postoperatively. Tumor size, serum tumor markers, and patient age have been proposed as risk factors for malignancy. This article reports a rare case of a giant, benign MCT of the ovary in a young woman (25 years old). It had a very large size (320 x 270 x 185 mm, 10 kg), a great number of teeth (> 300), and preoperative serum level of tumor markers were elevated (CA125, 875 U/mL(-1); CA19-9, 2087 U/mL(-1); CEA, 5.1 ng/mL(-1); AFP, 23.3 ng/mL(-1); SCC, 20.7 ng/mL(-1)). Based on clinical and laboratory data, tumor markers and tumor size when used alone or in combination do not appear to be useful in making a differential diagnosis between MCT and squamous cell carcinoma arising from MCT. However, radiologically detectable, well-differentiated teeth may be indicative of benignity.
卵巢成熟囊性畸胎瘤（MCT）恶变肿瘤的术前诊断并不容易；大多数恶变肿瘤仅在术后才能确诊。肿瘤大小、血清肿瘤标志物和患者年龄已被提出作为恶变的危险因素。本文报道了一例罕见的年轻女性（25岁）卵巢巨大良性MCT病例。其体积非常大（320×270×185mm，10kg），有大量牙齿（>300颗），术前血清肿瘤标志物水平升高（CA125，875U/mL⁻¹；CA19-9，2087U/mL⁻¹；CEA，5.1ng/mL⁻¹；AFP，23.3ng/mL⁻¹；SCC，20.7ng/mL⁻¹）。根据临床和实验室数据，单独或联合使用肿瘤标志物和肿瘤大小似乎无助于鉴别MCT与MCT来源的鳞状细胞癌。然而，影像学可检测到的、分化良好的牙齿可能提示为良性。
